university-technology.com

graphic version

Home
About Us
Markets
Partners
Success Stories
Technology Search
Register
Contact Us
Useful Links

Search Technologies

Our database of opportunities is constantly being updated as new technologies come on stream. To keep up to date with new developments in your area please click here to register.

You can search the database of technologies by market sector, opportunity type or keyword. Click on the help link if you require help.

Market Sector:				help
Opportunity Type:				help
Key Word(s):				help

Automotive & Aviation

Deoxygenation (Licensing)
Researchers at The Robert Gordon University have created a ceramic catalytic reactor for deoxygenating a fluid.

Eco-Friendly Fire Retardant Foams (Licensing)
Researchers at the University of Strathclyde’s Department of Pure and Applied Chemistry have developed eco-friendly fire retardant polyurethane foams. The main benefits of the technology include increased effectiveness in the prevention and spread of fire; and the use of environmentally friendly non-toxic materials. The technology is relatively inexpensive in comparison to existing formulations, and is readily adoptable into existing manufacturing processes. These foams can be used in many industries including furniture and soft furnishings, construction, packaging, automotive and aeronautics.

Industrial Psychology Research Centre (Collaborative)
The Industrial Psychology Research Centre at the University of Aberdeen specialises in the application of psychology to the management of health, safety and emergency response in the workspace, particularly for high reliability organisations. Established in 1987 the Centre has research and consultancy experience within the oil and gas industry, nuclear and conventional power generation, civil aviation, the emergency services and hospital medicine.

Micro-Texturing of Irregular Surfaces (Licensing)
Surface micro-geometries (smg’s) have been found to result in performance improvements in many applications. Micro-texturing can reduce wear on mechanical components by improving lubrication effectiveness and the cooling capacity of many materials by increasing their surface area.Pioneering work at the University of Strathclyde has produced a tool-system capable of creating smg’s of depths 0.5μm on surfaces with an undulation range of 50μm. The piezo-ceramic actuator and force-limiter (the main elements of the tool-system) enable delivery of a precisely prescribed force to the target surface, regardless of variations in the space between the indenter and the target surface.

Severe Plastic Deformation Process for the Nanostructuring of Metals (Collaborative)
Nanostructured metals draw substantial interest due to their unique mechanical and physical properties. For instance, at low temperatures, an ultra fine grain size (<1 μm) doubles the strength and toughness of the material and, at high temperatures, leads to superplastic behaviour. A new Severe Plastic Deformation (SPD) process has been developed at Strathclyde which can be conducted in a batch or continuous manner. It uses a system of dies through which the metal is passed and strained. The process allows for metals to be restructured, enabling production of a variety of nanocrystalline metals with various properties.

Silicon Carbide Microsystems (Licensing)
The University of Edinburgh technology provides a method and apparatus for fabricating microelectromechanical (MEMs) systems and, in particular, for producing silicon carbide (SiC) MEMs devices with greatly improved mechanical properties. Although a range of silicon MEMs are commercially available, SiC MEMs devices are superior for use in harsh environments including locations of high temperature, high vibrational frequency, high wear and those containing corrosive media. The present invention provides a one-step dry etching method for the fabrication of suspended SiC cantilever and doubly clamped bridge structures as used in common MEMS structures.

Surface engineering of metals and oxides (Collaborative)
Surface Chemists at the University of Edinburgh and University of Canterbury in New Zealand have developed an innovative approach to protection and engineering of metal and oxide surfaces. This new approach offers an alternative to conventional chromium-based anti-corrosion treatments. In addition, it can be combined with surface chemical functionality, with the potential to impart valuable properties in a variety of applications.

The Scottish Offshore Materials Centre (SOMC) (Consultancy)
SOMC is a new facility funded by a Research Development Grant and is located within the University of Aberdeen’s Engineering and Chemistry Departments. At the heart of SOMC is a state of-the-art High Pressure-High Temperature (HP-HT) test facility that is dedicated to the needs of manufacturers and users in the oil and gas, petro-chemical, chemicals and energy sectors. The facility allows the testing of materials, components, equipment and geological materials under typical HP-HT downhole service conditions.

Biotechnology

3D-Electroforming of Polymer Microstructures (Licensing)
Heriot-Watt University researchers have developed an electroforming technology capable of high resolution patterning of planar and 3-Dimensional surfaces, specifically internal and external curves. This versatile technology is applicable to the manufacture of microfluidics devices, micro-optics and functional surfaces. Protected by a GB patent application partners are now welcome for cooperation on the further development and commercialization of the technology.

A Novel Drug Delivery Strategy for Nasal MRSA Eradication (Licensing)
MRSA (methicillin resistant S. aureus) is a potential killer infection that is endemic in our hospitals. Around 20% of the general population (patients, staff, hospital visitors) are believed to be carriers with potential to cause infection. A research team at the University of Strathclyde has demonstrated that the use of novel formulations results in rapid adherence to the nasal mucosa by formation of viscous gels that resist removal by cilia. A sustained absorption profile is obtained, leading to reduced frequency of dosing. The novel nasal formulations (NNF) are virtually sensation free and afford prolonged residence in man.

A Novel Kinase (SGK) Target for the Treatment of Diabetes, Cancer and Stroke (Licensing)
A team of research scientists at the Wellcome Trust Biocentre at the University of Dundee have developed specific inhibitors and activators of protein kinases in the insulin signalling pathway with the aim of identifying novel drug targets for a variety of diseases including diabetes, cancer and ischaemic injury.A method of modulating SGK activity has been developed providing a screening method for new drugs or lead compounds.

Advanced Compression Software for Microscopy Images (Licensing)
A unique image compression system has been developed in the Computing Science Department of the University of Glasgow.Developed to run under the Windows TM environment the codec reads stacks of .tif files although it can be expanded to handle other image formats. A whole stack of microscopy images is compressed to a single file.The codec is incorporated in a stack viewer package that allows data to be viewed along orthogonal axes, and allows maximal isometric projections of the data.Compression ratios can be selected.Monochrome and colour stacks are supported. This technique utilises Lossy compression – therefore it is not suited to clinical diagnostics.

Anti-cancer compounds:novel non-genotoxic activators of p53 (Licensing)
In a collaborative project between the Universities of Dundee and St Andrews a series of compounds activating the p53 tumour suppressor have been identified. Data is available showing one of these compounds preferably kills tumour cells expressing normal p53 and reduces tumour growth in a xenograft model.

Antimicrobial Agent Targets in Acanthamoeba - A treatment for contact-lens induced infection (Licensing)
Acanthamoeba are microscopic amoeba commonly found in the environment. Through improper storage, handling, and disinfection of contact lenses, Acanthamoeba can enter the eye and cause severe ulcerations of the cornea - a condition called Acanthamoeba keratitis. Current treatments are extremely cumbersome and often fail as Acanthamoeba can develop into cysts that are resistant to the drugs used to treat it. Even if successful, the damage to the eye can be so extensive that a cornea transplant is required. Moreover, the drug-resistant cysts remaining in the eye can re-infect the transplanted cornea.

Binding Site for Zinc in Human Albumin (Licensing)
Professor Peter Sadler’s group at the University of Edinburgh have discovered a binding site for zinc in human albumin. Albumin is the major transport protein in blood plasma and can reversibly bind a wide range of molecules. Although approximately 75% of circulating zinc in the blood is bound to albumin, the binding site had not previously been known. The binding site is highly conserved across mammalian sequences and offers an important insight into metal binding regulation.

Bio-Chip with Integrated Nano-Waveguides for High Performance Optical Analysis (Licensing)
Researchers at the University of Glasgow have adapted methods from the telecommunication industry to fabricate ‘biochips’ which integrate optical and micro-fluidic components.

Biodegradable transfection reagents (Licensing)
Cell transfection with nucleic acids is the optimal way to express or inhibit proteins within cells. Researchers at the University of Edinburgh have synthesised a unique class of biodegradable, non-toxic cationic lipids that exhibit excellent transfection efficiencies in primary and stem cell lines, in addition to well known immortalised varieties.

Breath Monitoring for Ethane Gas (Licensing)
This opportunity has developed from high sensitivity ethane gas sensing applications in the oil industry. A number of potentially valuable clinical applications are now being investigated as part of a Scottish Enterprise Proof of Concept project. The Universities of Glasgow and Dundee welcome enquiries from any organisation interested in discussing exploitation routes for this exciting development.

CDK inhibitors enhance the resolution of the inflammatory response (Licensing)
Scientists at the University of Edinburgh have identified a novel therapeutic strategy for the treatment of inflammatory disorders. Cyclin dependent kinase (CDK) inhibitors were shown to enhance the resolution of inflammation by inducing neutrophil apoptosis. The discovery has applications in treatment of chronic, acute and fibrogenic neutrophil mediated inflammation.

Cell-Culture System for Neurotoxicity Tests (Collaborative)
Cell death and degeneration involved in nervous system disorders shows specific patterns, related to cell type (neurones vs. glia) and cell-death type (acute, delayed, apoptotic or necrotic). Cell death, as well as rescue mechanisms, involve interactions between cells via factors released (e.g. cytokines), which can be both beneficial and detrimental. Current screening methods are not able to differentiate between the cellular characteristics of different nervous system disorders. The University of Aberdeen are developing advanced neuronal cell culture systems which will mimic the main hallmarks of some of the major nervous system disorders (e.g. Alzheimer’s disease, inflammatory responses, stroke).

Centre for Biomedical and Nutritional Sciences (Spin-out)
BIO is virtually unique within UK Universities. No other single academic unit encompasses such a broad range of subjects / disciplines in its research portfolio. It has ‘opposite ends’ in biomedical and nutritional research that includes – cell & molecular biology; proteomics; food analysis; nutritional intake in childhood; microbiology of bacterial and viral pathogens; fungal toxins; physiology of tissue injury and modeling; pharmacology; cardiovascular and respiratory function; genetic diseases and cancer.

Centre for Risk and Governance at Glasgow Caledonian University (Consultancy)
Glasgow Caledonian University possesses unique national and international expertise in a number of areas applied to Governance and Risk. This is embedded across the University’s eight Schools and also several Divisions.

Centre for Vision in Health (Licensing)
Glasgow Caledonian University has built a solid foundation of multi-disciplinary vision research. The Centre for Vision in Health further develops this expertise via enhanced contributions by researchers in optometry, physiology, biochemistry, psychology, physics, and microbiology. Additional medical links via the appointment of two senior academic consultant ophthalmologists have also been developed.

Clinical Assessment Software Tools for 3D Surface Anatomy Imaging (Licensing)
The University of Glasgow has developed practical clinical assessment tools that utilise 3D images of the surface anatomy of a patient and which are also compatible with conventional 3D volumetric medical imaging data sources such as CT and MRI. Surface anatomy analysis algorithms, developed as part of an ongoing research programme, have been integrated with advanced statistical algorithms and packaged into a suite of intuitive, easy-to-use software tools that give the clinician significantly enhanced capabilities and can also be used to extend the capability of existing 3D volumetric data analysis techniques. Algorithms have also been devised to support statistical analysis of the true 3D shape of the imaged anatomy based on comparison of reference statistics derived from 3D images of a control group. The University is keen to begin the commercial exploitation of this technology and seeks a suitable commercial partne

Combating Pathogenic Bacteria (Licensing)
The potential for bacteriophages to control bacterial infections has been known for some time, but not fully exploited. They are not commonly used in general medical practice due, in part, to the introduction of antibiotics. However, the overuse of antibiotics has resulted in many bacterial species which have become resistant to antibiotics, a large number of which are pathogenic and expensive to treat. These include the MRSA ‘superbug’.

Compounds for the development of novel asthmatic therapies and infectious diseases (Licensing)
Researchers at the University of Dundee have identified a number of novel compounds that inhibit family 18 chitinasees.Specific potent inhibitors would be of considerable interest for the development of novel therapeutics with anti-fungal,or anti-inflammatory potential for asthma and other disorders.

Cytochrome P450 CYP2S1 to aid the treatment of Psoriasis (Licensing)
Researchers at the University of Dundee have shown that the human cytochrome P450, CYP2S1, is expressed in human skin with marked individuality in expression and induction following UVR or topical drug treatment. These data suggest a functional role for CYP2S1 in the metabolism of topical drugs, leading to improved therapeutics for psoriasis patients. A commercial partner is now sought for the development of this technology through either research collaboration or licensing.

Decontamination of surgical instruments with MIDAS (Licensing)
The University of Edinburgh has developed new methods for cleaning surgical instruments, which completely remove protein contamination, including prions - the infectious agents that cause Creutzfeldt-Jakob Disease (CJD) in humans. The methods, known collectively as MIDAS, use radiofrequency (RF) gas-plasma technology and are highly effective in removing contamination, including protein, from a variety of surfaces. Biological assays using infective implants have verified that the technique eliminates TSE infectivity.

Defined media for culturing regionalised anterior endoderm cells (Licensing)
Researchers at the University of Edinburgh have developed a defined media and serum-free process for the isolation of anterior definitive endoderm (ADE) cells from mouse embryonic stem cells. This technology offers the potential to develop a commercially available defined media for generating ADEs to improve the derivation of important gut-associated organ cells as well as providing a new set of markers from gene profiling for directed differentiation.

Deoxygenation (Licensing)
Researchers at The Robert Gordon University have created a ceramic catalytic reactor for deoxygenating a fluid.

Detection, alleviation, elimination Arsenic and heavy metal pollution in water (Collaborative)
Arsenic pollution in groundwater is an acute global health problem. There is a recognised need for improved arsenic specific biosensors detecting both the bioavailability and these low ranges with increasing sensitivity to detect the toxin in water. Napier scientists, who have the background intellectual property in this area, have the capability of addressing these needs with the development of a new biosensor with the capability of achieving the required measurement sensitivities. Specifically, the capabilities are vertically tiered to (i) detect the arsenic at location (ii) remove the pollutant at source (bioremediation) and (iii) treat patients showing signs of disease.

Development of Anti-Obesity Compounds (Licensing)
Obesity is a common and increasing problem. US government estimates show that 33% of people aged 20 to 74 are obese which attributes to 100,000 deaths annually, and is a major cause of heart attacks, high blood pressure, strokes, diabetes, sexual dysfunction, bowel cancer, and arthritis. Estimates of the market size for a drug treatment of obesity are $4-5 billion annually. Current therapies are inadequate however as they rarely produce a sustained weight loss and have unacceptable side-effects.

Diagnostic Biomarkers for Ectopic Pregnancy (Licensing)
Scientists at the University of Edinburgh’s Centre for Reproductive Biology have identified novel biomarkers that allow the rapid identification of an ectopic or extra-uterine pregnancy. They have been identified in the first trimester of the pregnancy, rapidly speeding up the diagnosis of a non-viable pregnancy.

Diagnostic for genetic predisposition to Autism with therapeutic potential (Licensing)
This technology developed at the University of Aberdeen relates to the discovery of mutation of a single gene in individuals with classical autism. The gene is involved in protein translation and offers possibilities in the diagnostic and therapeutic markets for those with autism spectrum disorder.

Drug-Eluting Stent for High Risk Patients (Collaborative)
Stent implantation is a highly effective treatment for restoring blood flow through an atherosclerotic artery; however restenosis (a re-narrowing of the diseased artery) occurs in a significant proportion of patients. Drug-eluting stents have been developed to limit restenosis and although they represent a major advance, they have limited effectiveness in diabetic patients. In addition, the drugs that are used at present inhibit the regrowth of the endothelium which is required to protect the artery. Thus, there is a need for an improved drug-eluting stent that will be suitable for diabetic patients, will not harm the endothelium, and will protect against blood clotting.

Edinburgh Lead Discovery (Collaborative)
Structure Based Identification and Optimisation of Lead Compounds “Edinburgh Lead Discovery” is a consortium of University of Edinburgh experts that has developed from a portfolio of successful collaborative projects with both academic and industrial partners where structure based screening of targets has enabled lead-compounds to be identified and optimised.

Effective Delivery of Drugs to the Lung (Licensing)
There are a number of impediments to effective drug delivery. These can include erroneous absorption which reduces the concentration of the drug at the critical target site. In order to overcome this, researchers at the University of Strathclyde have pioneered a technique which delivers drugs through the use of a proprietary delivery system.

ES-62 – A Novel Anti-Inflammatory Agent (Licensing)
Chronic inflammation contributes to a broad spectrum of diseases including arthritis, psoriasis, diabetes, allergy, connective tissue diseases and heart disease. Despite the range of current therapeutics on offer, there is unmet clinical need as treatments such as corticosteroids, though often effective, are associated with serious side effects.

Fluid-Bicontinuous Particle-Stabilized Gels (Licensing)
Colloid scientists at the University of Edinburgh have invented a new generic route to gel formulation, involving particles suspended in fluid-bicontinuous mixture of two solvents. These gels will have highly tunable properties (eg, shear modulus and yield stress), allowing these to be selected for different applications, such as personal care, foodstuffs, drilling muds, and pharmaceuticals.

Genetically modified industrial microbes for enhanced manufacture of antibiotics and other high-value fermentation products (Licensing)
Citric acid-producing strains of the fungus Aspergillus niger are highly efficient at metabolising glucose to the commercially important acid product. At the enzymic level, this extraordinary productivity depends on the properties of two enzymes: phosphofructokinase (PFK) and a non-energy conserving alternative oxidase (AOX). ANTICO, a collaborative project funded under the European Commission’s Fifth Framework, genetically engineered the metabolism of other microbial species to use these features and modify their use of glucose so that the production of a wide spectrum of other industrially important products was enhanced.

High Pressure Polymorph Screening (Licensing)
The University of Edinburgh has developed a new method of screening for polymorphs and solvates of drug compounds. The new high pressure screening concept has potential to revolutionise the way polymorph screening is conducted. We are now offering this unique service to pharmaceutical companies and specialist polymorph screening companies to complement conventional screening programmes for new and existing drug compounds.

HTR Telomerase Promoter - Improving Suicide Gene Therapy for the Treatment of Cancer (Licensing)
We have developed an Adenoviral Construct containing the telomerase hTR promoter to provide highly efficient, cancer specific transcriptional regulation capable of targeting a broad range of cancer types. The University are currently seeking commercial partners with which to develop the use of the hTR telomerase promoter and to advance the lead constructs under development. We welcome enquiries from any company interested in evaluating our telomerase program for in-licensing or co-development.

Identification of New Protein Families Possessing PH Domains with Novel Phosphoinositide Binding Specifities (Licensing)
Researchers at the University of Dundee have identified three new mammalian protein families which show significance in a variety of cellular pathways. These provide drug targets for the treatment of cancer, strokes and diabetes.

Imaging Systems for Animated and Non-Animated Cardiac Images (Licensing)
Researchers at the University of Glasgow working with Cardiologists at the Western Infirmary have developed an imaging system for animated and non-animated cardiac images. The University are seeking commercial partners to explore the commercialisation of this technology.

Improved Method of Male Fertility Testing (Licensing)
Aerospace Engineers at the University of Glasgow, working with colleagues from the Section of Reproductive and Developmental Medicine at the University of Sheffield, have developed an improved method of testing male fertility. The University are currently seeking interested parties to discuss the commercial exploitation of this research.

Improved Scanning Microscope Source (Licensing)
In recent years confocal laser scanning microscopy has become one of the most widely applied and versatile microscopy methods in the fields of biology, medicine, engineering and physics. This technology produces a source which can be used for either confocal or multi-photon laser scanning microscopy which is cost-effective, low maintenance and easy to manipulate.

Improved ‘humanised’ mouse model technology: Recombinase Mediated Genomic Replacement (RMGR) (Licensing)
Researchers at the University of Edinburgh have perfected a genetic engineering strategy in mouse embryonic stem cells to replace large regions of mouse chromosomal sequences (>100kb) with the corresponding human syntenic region.

In-Situ Heavy Metal Sensor for Contaminated Land (Licensing)
Researchers at The Robert Gordon University have developed an in-situ heavy metal sensor for contaminated land. Currently samples of soil are taken at a variety of depths at suspected contaminated land sites. These are then transported back to the lab and analysed on a workbench-based spectrometer and results are conveyed back to the customer. Market research shows that existing end users are not entirely satisfied with this service. The new technology developed by The Robert Gordon University can provide an alternative that guarantees a prompt, cheap and effective result.

Intelligent Cardiovascular Stent (Licensing)
The use of stents has revolutionised coronary artery disease, however the main disadvantage is the occurrence of restenosis in 20-30 per cent of cases. As in-stent restenosis is not monitored as standard practice, diagnosis only occurs when the patient presents with symptoms. The key benefit of this technology is the ability to introduce economical occasional (clinic), or continuous (acute) monitoring of the in-stent restenosis, transmitting this data to a device outlside the body. Patients progressing to a restenosis situation, which could lead to cardiac infarction and possible death, can therefore be identified and treated.

MBD3-deficient embryonic stem cell line (Licensing)
Researchers from the University of Edinburgh have generated a pluripotent (murine) embryonic stem cell line and have shown that these MBD3-deficient stem cells are maintained in the absence of any exogenous factors (e.g. serum or LIF). Upon the addition of MBD3 back to the cells, the cells are able to differentiate into identifiable bone, muscle, skin, fat and neuronal tissue.

Meaningful Measurement for Rehabilitation, Sport, and Fitness &Leisure activities. (Consultancy)
An Instrumented Balance Assessment and Rehabilitation System (IBars) has been designed, constructed, and operated in a Clinical environment for more than two years. So far reliability tests, research results, and anecdotal feedback have all shown positives. The significance of quantifying balance both to Health Care providers and in the sports, and Fitness & Leisure markets must not be under-estimated. Balance and control of movement is being increasingly recognised as the forgotten factor in performance. Balance rehabilitation and quantification has applications through a wide range of client groups, from patients recovering from stroke to elite athletes.

Methanesulfonanilides for the treatment of inflammatory disorders (Licensing)
Scientists at the University of Edinburgh have identified a hitherto unrecognised potential of IKr-specific Class III anti-arrhythmics for the treatment of inflammatory disorders in a number of disease states/models. Class III anti- arrhythmics can modulate the recruitment of inflammatory leukocytes and phagocytosis of apoptotic infiltrated cells. The discovery has application in treatment of chronic, acute and fibrogenic mediated inflammation.

Method to determine best buffer to maintain proteins in solution (Licensing)
A method to enable the rapid identification of optimal conditions for maintaining proteins in solution has been developed by the University of Dundee. This overcomes current problems in maintaining sufficient quantities of proteins in solution for further evaluation.

Methods for the Identification and Treatment of Multiple Organ Failure (Licensing)
Researchers at the University of Edinburgh have identified potential compounds for the prevention and/or treatment of multiple-organ failure, as well as methods for monitoring the multiple-organ failure status of a patient.

Micro LED Arrays (Licensing)
Micro-LED arrays provide a fundamental technology which can underpin several significant markets. The display and lighting industry world-wide is being revolutionised by the advent of high brightness light emitting diodes (LEDs). Gallium nitride (GaN) materials technology is being used to provide devices at the blue end of the spectrum (violet/blue/green) and the same technology forms the basis of white light LEDs. The geo-political environment of recent years has resulted in enormous sums being invested in chemical and biological sensors and biomedical diagnostics both at point of care and in the lab are rapidly growing markets. The Institute of Photonics has developed and demonstrated a range of microLED arrays in various formats, all based on GaN growth on a sapphire substrate.

Miniaturised Sensor of Thermal Changes in Biological Samples (Licensing)
A research team at the University of Glasgow have developed a miniaturised high throughput sensor device that can be used to detect thermal changes in biological samples.

Molecular tool to drive Amygdala specific gene expression (Licensing)
This novel enhancer sequence is capable of supporting tissue specific gene expression in the medial amygdaloid nucleus and the sensory ganglia. This enhancer sequence offers the opportunity to study gene expression in a region of the brain clinically relevant for depression.

Monoclonal Antibody as novel therapy and biomarker for Acute Myeloid Leukaemia (Licensing)
Studies in patients with AML have identified a new target for the diagnosis and treatment of AML. A monoclonal antibody has been developed providing a novel therapeutic for this condition and other proliferative diseases of the haematopoietic system. This provides an new opportunity for both the diagnosis and treatment of AML.

Monoclonal antibody to Streptavidin-binding protein (Licensing)
Researchers at the University of Edinburgh have generated a monoclonal antibody to the streptavidin binding epitope tag widely used in affinity purification of proteins.

MRI Brain Temperature Mapping (Licensing)
Increased temperature is common following stroke and may increase the potential for damage. Therefore monitoring such pyrexia may be crucial in predicting prognosis and indeed directing intervention in stroke patients. Researchers at the University of Edinburgh have developed software to be used in conjunction with scanning instruments that allows non-invasive monitoring of brain temperature. The technique adapts data from magnetic resonance spectroscopic imaging (MRSI) to create a colour temperature contour map revealing increased temperature associated with the stroke. This gives detailed information on brain temperature and has demonstrated elevated temperature associated with ischaemic tissue and surrounding “penumbra”.

Multiplexed High Content Screening Assay (Licensing)
Researchers at the University of Edinburgh have developed a High Content Screening (HCS) assay which allows the near-simultaneous measurement of three separate cellular parameters, indicating the activity of the neuronal synaptic vesicle (SV) recycling pathway and cell death. These parameters are implicated in many neurological disorders, allowing the assay to be used to screen for compounds which affect neuronal behaviour, leading to the discovery of new treatments for such diseases.

Nanometric Environments and Adhesion Properties (Licensing)
The University is currently seeking commercial partners with which to further our research and develop the applications for use of this technology in a number of areas. We can offer: · Platform technology, which has the potential to be developed for use in a range of medical device applications. · In vitro/in vivo proof of principle in a number of materials with the potential to impact greatly on the biomedical device market and other areas. · Extensive expertise in the fields of nanotopography and cell biology. We welcome enquiries from any company interested in evaluating this technology for in-licensing or co-development.

New Target for Antimicrobial Compounds (Licensing)
A potential target for antimicrobial compounds has been developed by researchers at the University of Dundee. The highly purified target protein shows strong affinity for bacterial rRNA and is the only DEAD box protein for which a specific substrate has been identified.

Non-Invasive Blood-Circulating Molecule Extraction and Analysis Device (Licensing)
Control of blood glucose levels through glucose measurement and insulin injection can reduce the occurrence of complications in type 1 diabetes. Methods such as the ‘finger-stick’ technique have proven expensive, cumbersome and painful to use. Research from the University of Strathclyde has pioneered the first portable and programmable device for measuring blood glucose levels which can also detect other blood circulating molecules such as lactate.

Non-invasive Intelligent Wound Monitor (Licensing)
Optimum moisture balance at the wound-dressing interface is a key element in wound healing. At present there is no way of measuring the moisture balance at the wound-dressing interface other than to remove the dressing for inspection. This can, however, disrupt the healing process. Scientists at the University of Strathclyde have developed a novel technology which allows the moisture level of a wound to be measured using a non-invasive wound dressing monitor.

Novel Anti-Bacterial Compounds with a Rapid Bactericidal Action (Collaborative)
There is an urgent requirement for new anti-bacterial agents with novel mechanisms of action. One class of compounds with potential in this area is DNA Minor Groove Binders (MGBs). Drugs recognising specific regions of DNA achieve high levels of selectivity and efficacy because they interrupt the biochemistry of a cell at the fundamental levels of DNA replication or transcription of key genes.

Novel Anti-Fungal Compounds with a Rapid Fungicidal Action (Licensing)
There is an urgent requirement for new anti-fungal agents with novel mechanisms of action. One class of compounds with potential in this area is DNA Minor Groove Binders (MGBs). Drugs recognising specific regions of DNA can achieve high levels of selectivity and efficacy because they interrupt the biochemistry of a cell at the fundamental levels of DNA replication or transcription of key genes.

Novel compound for the treatment of psoriasis (Licensing)
Psoriasis is a skin disease characterised by inflammation and scaly lesions of the skin affecting 2-3% of the population in Europe and North America. Several different therapies are currently being used to treat psoriasis, but they all have the possibility of serious side effects. Additionally, they are expensive to produce and lack efficacy in some patients.

Novel compounds that regulate Angiogenesis, Cell Migration and Matrix Synthesis (Collaborative)
Chronic wounds are a major clinical problem caused by failure in one of the cascade of events underlying the normal wound repair process. MSF is an ideal candidate for a topical therapeutic to 'kick-start' normal healing as it induces all the cellular events required for wound repair. The high expression of MSF in fetal skin and adult gingival tissue is thought to be the reason why these tissues heal so well without any scarring.

Novel DNA Sequencing Tools (Licensing)
Researchers at the University of Glasgow have developed a new tool for rapid execution of DNA sequencing. The University is currently seeking partners interested in the commercial explotation of this research.

Novel High Sensitivity Multiplex Detection System for Molecular Diagnostics (Licensing)
Currently, molecular diagnostics is dominated by the use of fluorescent labels to detect DNA sequences. This process can often be costly and time-consuming due to the number of separate experiments required. In order to obviate such problems, a research team at Strathclyde has developed a patented, highly sensitive multiplexing technology for labelling and analysing DNA and other potentially useful biomarkers.

Novel polymeric nano-carriers for drug delivery and other biomedical applications. (Licensing)
Researchers at The Robert Gordon University have engineered novel nano-sized polymeric solubilisers to encapsulate and deliver therapeutic agents such as peptides, proteins and water insoluble drugs. In the aqueous solution, these delivery systems form a protective core, which can trap and separate their cargo from the aqueous environment. Hence, they can also be designed to carry potent substances, which are easily degradable in an aqueous environment during processing/manufacturing. They are easy to prepare and due to the diverse architecture of these delivery systems, they can be tailored made to carry a broad range of molecules for biomedical application

Novel Sedatives and Hypnotics from Valerian (Collaborative)
Extracts of valerian plants are widely and successfully used as sedatives. Preparations of plant materials are, however, variable in composition and in effectiveness. Moreover, the active components have not been identified. Some isolated components, such as valepotriates, baldrinals and valerenic acid have been studied, but their sedative activity does not explain the potency of the original extracts. The overall effect of the extract is widely assumed to result from synergistic actions of several components, although this has never been demonstrated.

Novel Solid State Sensor for Positron Emission Tomography (PET) (Licensing)
This technology, developed at the University of Aberdeen, relates to a new sensor for use in Positron Emission Topography (PET). PET is a technique in which compounds are labelled with positron emitting isotopes and a 3-dimensional image of their distribution is produced. As well as being a direct replacement for existing sensors in current generation scanners the sensor we are developing has the potential to open up a new market of portable scanners that would find applications, for example, in intensive care and cancer screening.

Novel therapy for inflammation: a recombinant viral protein (Licensing)

Researchers at the University of Glasgow and the University of Birmingham have discovered a herpesvirus immunomodulatory protein called vOX2.

It is encoded by the Kaposi’s sarcoma-associated herpesvirus (KSHV). We have proven in vivo that a recombinant derivative is anti-inflammatory (Rezaee et al., 2005). Our recombinant protein combines vOX2 with the Fc portion of a human antibody: it is called vOX2:Fc and is potentially therapeutic. It is secreted from CHO cells, an industry standard for this application, facilitating its purification in milligramme quantities.

Novel Tyrosine Kinase BRK as a Target for Cancer Therapy (Licensing)
Researchers at the University of Glasgow have identified a novel therapeutic target for cancer. Recent published work has identified BRK as a potential therapeutic target in breast cancer and it is predicted that drugs developed and targeted to the BRK enzyme will affect the proliferation of breast cancer and other tumours over-expressing the product. The University of Glasgow is seeking to licence this intellectual property to third parties who are interested in developing the research further.

Optical Fractionation and Sorting (Licensing)
Optical microfluidic sorting will allow biological or other matter to be sorted or fractionated by criteria including size, shape, density and refractive index. The technique may have the ability to sort matter from the scale of macro-molecules all the way up to large cells. In addition to the technical advantages of optical sorting and fractionation, the inherent simplicity of the approach could allow the system to be integrated with the existing laboratory equipment currently found in any research lab or hospital. This method allows a non-invasive technique for the sorting, separation and analysis of biological matter.

Optical Manipulator (Licensing)
Scientists at the University of Edinburgh have developed a user friendly optical manipulator that interfaces to a standard port on most research grade microscopes. Ongoing development in the COSMIC laboratory has demonstrated applications in single cell and molecule studies. Many potential applications exist in the physical and life-science fields.

Optical Micro-rotator (Licensing)
A new “Optical micro-rotator” system incorporates apparatus for and a method of rotating microscopic objects using a beam of electromagnetic radiation. In order to rotate an object a microscopic, non-circularly symmetric distribution of electro-magnetic radiation is projected on to a region containing the object. This causes photons in the beam to refract around the object imparting a controlled rotation to the microscopic objects by exerting optical gradient forces on them.

Optimal fill pattern template for use in Osteochondritis operations using mosaicplasty (Licensing)
This operation involves the cutting out of cylindrical shaped areas from a diseased knee. These are then filled with smaller cylindrical plugs/grafts from a healthy part of the knee. Currently this operation involves the orthopeadic surgeon ‘guessing’ which size of grafts to use and how to arrange them in the whole for maximum coverage. Templates developed by Glasgow Caledonian University detail the size of the cylinders required, the combination of grafts to be used to refill the hole and the arrangement required to give an optimum fill. Removing the need for guesswork on the part of the surgeon.

Oral Vaccine System (Licensing)
The traditional method of administering vaccinations is by injection. This method suffers from high relative cost, low efficacy and compliance and the need for trained personnel for administration. Researchers at the University of Strathclyde have developed a system which enables the oral delivery of vaccines - “bilosomes”. This represents a major step forward in vaccine technology.

Organ preservation solutions to improve clinical outcome from organ transplantation (Licensing)
Scientists at the University of Edinburgh have collaborated with transplantation surgeons to explore the possible benefits of novel additives to organ preservation solution. The purpose of the research was to increase the length at which organs can be preserved prior to transplantation. The preservatives work by boosting endothelium-derived agents such as nitric oxide, which improves the survival of endothelial cells in blood vessels, helping protect against vasospasm and thrombosis.

OSCAR™: High Yielding Protein Expression System (Licensing)
Researchers at the University of Edinburgh have developed OSCAR™, a protein expression system with the potential to form a platform technology which will simplify the method of protein production in cultured mammalian cells. This system is simpler and quicker to use and has already been shown to produce high yields of a hormone and an antibody, at levels that outperform commercial systems.

Oxidative Stress Probe (Licensing)
A collaboration between The Rowett Research Institute and The Robert Gordon University has lead to the development of a sensitive fluorescent probe for cellular oxidative stress determination. In its natural 'unoxidised' state, the compound is highly fluorescent. It is rapidly distributed within cells and appears preferentially concentrated within mitochondria. Oxidative stress induces a stress-dose related decrease in the level of fluorescence emission. Fluorescence change has been successfully monitored by fluorescence/confocal microscopy but may be measured on alternate fluorimetric platforms. The subcellular distribution of the probe also renders it useful as a sub cellular stain.

Oxygen-Scavenger Packaging (Licensing)
Oxygen has many destructive properties and often there are instances where presence of the element is not desirable. Such circumstances might include electronic and opto-electronic devices and modified atmosphere packaging manufacture. Oxygen scavengers act to reduce the concentration of oxygen in order to preserve the life of the substance it aims to protect. The scavenger developed at Strathclyde is made of a photocatalyst such as TiO2 which, upon irradiation, deoxygenates a closed environment. The scavenger is embedded within a film which can be used to cover electronic, optoelectronic devices or protect foodstuff or medical instruments.

PACT: A new approach to PhotoActivated ChemoTherapy (Licensing)
Researchers at the University of Edinburgh, led by Professor Peter Sadler, have developed a novel series of platinum prodrugs, which can be activated by light (photoactivated). In partnership with Dr Julie Woods, at the University of Dundee, these prodrugs have been shown to exhibit cytotoxic activity in vitro. We believe this offers a novel approach to platinum chemotherapy to significantly reduce associated side effects and introduce a new mechanism of action.

Plasma Treated Active Carbon Adsorbents (Licensing)
Researchers at The Robert Gordon University have developed a completely new type of porous carbon for high performance filtration. The materials provide a pivotal role in the successful development of key technologies to meet current societal needs in the critical areas of energy, purification and safety/personal protection where the development of new, low cost, safety clothing and breathing apparatus for civilian and military protection against the threat of terrorist attacks is an ever increasing need.

Portable Magnetic Resonance Imaging (MRI) (Licensing)
The technology, developed at the University of Aberdeen, relates to the portable MRI system which will cost significantly less than current equipment. Most existing magnetic resonance imagers are highly sophisticated, occupy a large amount of space and are costly to purchase and maintain. There are numerous situations in which the ability to image small objects or localised areas of human or animal patients using portable equipment would be extremely valuable.

Prion-specific antibody (Licensing)
Researchers at the University of Edinburgh, together with colleagues from the Scottish National Blood Transfusion Service, Roslin Institute Neuropathogenesis Unit, and the University of Strathclyde, have developed an antibody that can distinguish abnormal PrP (PrPSc) from the normal cellular form (PrPC). This is a major step towards the provision of a rapid and reliable screening test for the presence of the disease-associated form of the prion protein applicable to donated blood and organs for transplantation.

Probiotic Micro-Organisms (Collaborative)
Researchers at Heriot-Watt University have developed a range of probiotic micro-organisms which show protection against fish diseases such as furunculosis, enteric redmouth disease, vibriosis and winter ulcer disease. In addition these organisms provide a dietary supplement to enhance the growth and health for a wide range of fish species.

Proprietary CpG Reagents to analyse the methylation status of all human genes (Licensing)
Researchers at the University of Edinburgh have identified two protein domains (MBD and CxxC) proven to isolate methylated and non-methylated CpG islands (CGIs), respectively. Using these proteins, a novel CGI enrichment technology, has been devised and proven to identify and separate bona fide CGIs.

Real Time Nitrate Detector (Licensing)
Researchers at The Robert Gordon University have developed a new method for detecting nitrates in foodstuffs and water. This new sensor membrane uses a compound that provides a robust solution to the limitations usually found surrounding the measurements of nitrates. By working with partners in Portugal and Spain, RGU has produced an electrode without an inner reference solution, producing a robust sensor which can detect to a limit of 10-7M – an improvement on the method currently used which struggles to detect concentrations below 10-5M.

Realtime Image Registration (Licensing)
Using a groundbreaking technique developed in astronomy, researchers at the University of Edinburgh are able to register complete 3D image volumes to sub-pixel accuracy in real-time. For the first time, full affine correction can be calculated and applied as an imaging sequence is acquired, vastly reducing both bulk subject motion and geometric artefacts from the images.

Scotin - a novel target for cancer therapies (Collaborative)
University of Dundee researchers have identified and characterised a novel gene inducible by p53. Scotin is a potential target for new cancer therapies and could also form the basis of new therapeutic compounds. A commercial partner is now sought for the development of this technology through either research collaboration or licensing.

Selectively enhancing nitric oxide activity in damaged blood vessels (Licensing)
Many drugs are aimed at enhancing the therapeutic potential of nitric oxide (NO) in the cardiovascular system. These generally lack selectivity, hence there is a need to treat diseased tissues more specifically in order to restore their function. This can be achieved by boosting the natural enzymatic synthesis of NO, which is impaired in pulmonary hypertension, atherosclerosis and diabetes. Supplementation of the natural cofactor of the enzyme (tetrahydrobiopterin) has clinical efficacy, but the compound must be injected.

Shinkanco: A Step Forward for Alzheimer's Research and Other Neurodegenerative Disorders (Licensing)
Shinkanco, a joint project between the universities of Glasgow and Strathclyde, has developed a portfolio of four early-stage programmes containing lead compounds that represent potential approaches to novel drugs to alleviate cognitive dysfunction in Alzheimer’s disease and related disorders. These include a novel protein involved in memory control, and a novel compound (and analogues) with structure unlike existing drugs.

Synbiotic for the Treatment of Ulcerative Colitis (Collaborative)
Researchers from the University of Dundee have developed a novel synbiotic formulation that promotes the growth of beneficial bacteria that will then play a key role in the treatment of ulcerative colitis. This treatment provides effective therapy by promoting the body's own defence system.

Synthesis of nucleoside triphosphates (Licensing)
Researchers at the University of Edinburgh have developed two novel and complimentary methods for syntheses of nucleic acids. These new systems employ polymer-supported reagents to generate nucleic acids.

Synthetic Low Density Lipoprotein for Serum-Free Tissue Culture (Licensing)
The recent explosion in molecular biology has led to increased demand for tissue culture media. Usually this media is supplemented with foetal calf serum which provides essential lipids to maintain cell viability and promote growth. Serum, however, is expensive and suffers from inherent biological variability, potential contamination from adventitious agents and increased regulatory scrutiny. This has led to the drive for serum-free media but until now there has been no real animal-free lipid supplement available.

Targeted therapy for specific autoimmune disease (Licensing)
A peptide is described that selectively inactivates pathogenic T-cells responsible for autoimmune disease. Potential applications of this therapy include for example rheumatoid arthritis, psoriasis, multiple sclerosis and autoimmune haemolytic anaemia

Technology for Improving the Accuracy of Fluorescence-Based High Density Microarray, Microplate or Biochip Readers (Licensing)
Researchers at the University of Glasgow have developed technology which aims to overcome some of the known problems associated with fluorescence-based screening of biological samples.

Test for chemotherapy drug resistance in lung cancer (Licensing)
Expression data from a set of tumour specific genes has yielded a patient profile that will predict success or failure of platinum-based chemotherapy. A test has been developed that identifies with very high degree of accuracy patients who will benefit from the standard platinum chemotherapy. Researchers are working toward validation in clinical trials and development of a robust assay for clinical practice.

Tools for rational drug discovery (Licensing)
Researchers at the University of Dundee have developed methods for determining the structures of molecules. Reagents and methods for crystallization of the proteins PDK1, PKB and TAPP1, can be used in co-crystallisation studies to design modulating molecules of best fit. PRODRG is a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules. These systems can be used to design more effective drugs.

Topical treatment for chronic neuropathic pain (Licensing)
Chronic neuropathic pain represents a largely unmet need. A research team at the University of Edinburgh has demonstrated that stimulating activity of a receptor involved in the sensation of cold using menthol, from mint or other synthetic agents, can trigger the relief of chronic and neuropathic pain.

UV Light Indicator (Collaborative)
The incidence of skin cancer has doubled in the UK in the past 20 years, now affecting 50,000 Britons every year. Protective sun creams are widely available, however if the lotion is not reapplied at the appropriate time or is rubbed or washed off, consumers are left at risk of being burned. Researchers at Strathclyde University have developed an innovative UV light indicator in the form of a simple wrist-band, which could solve this problem. A novel ink formulation printed onto the band produces a colour change warning the user once their exposure has reached recommended levels.

Virtual Screening Service (Licensing)
Despite the expansion in high-throughput screening, finding new drugs is still an expensive and time-consuming business. Virtual screening can increase drug discovery productivity by reducing the time and expense of identifying suitable development candidates. Thousands of potential hit compounds can be identified by virtual screening in a fraction of the time of high-throughput screening methods.

Chemicals

An Intelligent Ink for the detection of Photocatalytic Films (Licensing)
Self-cleaning glass and tiles coated with a photocatalytic semiconductor film have been on the industrial and commercial markets for some time now. Until now the stearic acid test has been the primary method of measuring photocatalytic activity. However, this is a complex, time-consuming technique and cannot be performed on products in situ. Novel technology has now emerged from the University of Strathclyde that overcomes the inherent difficulties of the stearic acid test.

Deoxygenation (Licensing)
Researchers at The Robert Gordon University have created a ceramic catalytic reactor for deoxygenating a fluid.

Hydrogen Peroxide Indicator Device (Licensing)
In recent years ‘kitchen-sink’ type explosives using commonly available ingredients have gained popularity amongst terrorist groups. These explosives are usually based on hydrogen peroxide which is commonly available. There is currently a concern that such peroxide based explosives could be generated at the site of a planned explosion. In terms of security and rapid screening, therefore, the rapid and simple detection of hydrogen peroxide is important in assessing the nature of unknown liquids, which may be potential explosive precursors. A team in the Chemistry Department at the University of Strathclyde have identified several triarylmethane dyes and other colour-changing systems that exhibit hyper-sensitivity towards hydrogen peroxide.

Mid-Infrared Spectroscopic Imager for Gases, Liquids and Solids (Licensing)
A novel detection and visualisation instrument which uses the back-scatter absorption imaging technique and takes advantage of the very high optical absorption exhibited by many different substances, including hydrocarbons such as methane, in the mid-infrared spectral range. The system therefore not only detects the presence of the substance under test, but also indicates where in the field of view it is, thereby allowing the operator to rapidly find its location. Concentrations of methane have been imaged down to approximately 40ppm.m - a level 500 times lower than the lower explosive limit of this gas.

Oxygen Intelligent Ink (Licensing)
Modified Atmosphere Packaging (MAP) is a modern and much used method to protect oxygen sensitive items, most commonly foodstuffs and sterilised medical equipment. It is imperative within this form of packaging that the level of oxygen is known, to indicate product tampering and assure quality. Current oxygen sensors tend to be unreliable, due to their reversibility with oxygen, and are also typically costly with short shelf-lives. New research at the University of Strathclyde has discovered a novel sensor for measuring oxygen levels within MAP.

Preparation of Enantiomerically Pure Chiral Amines. (Licensing)
Researchers at the University of St Andrews have developed a synthetic process for the preparation of a class of enantiomerically pure chiral amines. This efficient and economical method gives rise to entities of a varied structural class, which can be used as building blocks in the synthesis of bioactives or catalysts for asymmetric synthesis.

Self-sustaining Treatment for Active Remediation for Hazardous Industrial Contamination of Soil (Licensing)
Researchers at the University of Edinburgh have discovered an innovative solution for the remediation of a wide range of hazardous chemicals polluting the soil and water at industrial sites. Self-sustaining Treatment for Active Remediation (STAR) aims to effectively eliminate contamination by organic liquids, including coal tars, solvents, oils and petrochemicals. It is promising for both in-situ and ex-situ applications.

Wastewater remediation: Hydrocavitational Advanced Fenton Process (HCAFP) (Licensing)
HCAFP, pioneered by researchers at the University of Abertay Dundee, is a novel, patented process for the treatment of industrial wastewaters containing recalcitrant organic pollutants, such as those from the chemical sector. The process is an innovative development of a well-proven chemical oxidation reaction that provides a solution for the rapid and effective removal of these pollutants. Currently, a significant volume of effluent from the chemical sector is tankered off-site for disposal as it is not cost effective, or practical, to provide on-site treatment. By reducing the toxic organic content HCAFP can render these wastewaters amenable to traditional downstream treatment processes or potential direct discharge to sewer.

Communications

Advanced Compression Software for Microscopy Images (Licensing)
A unique image compression system has been developed in the Computing Science Department of the University of Glasgow.Developed to run under the Windows TM environment the codec reads stacks of .tif files although it can be expanded to handle other image formats. A whole stack of microscopy images is compressed to a single file.The codec is incorporated in a stack viewer package that allows data to be viewed along orthogonal axes, and allows maximal isometric projections of the data.Compression ratios can be selected.Monochrome and colour stacks are supported. This technique utilises Lossy compression – therefore it is not suited to clinical diagnostics.

Automatic Detection of Video and Film Copies Distributed on the Internet (Licensing)
AUTOMATIC DETECTION OF VIDEO AND FILM COPIES DISTRIBUTED ON THE INTERNET: A novel digital fingerprinting technique which can automatically detect copyright infringing video files on peer-to-peer networks via the Internet and other media. This technique relies only on information already present within the video. The identification of the video is robust and able to withstand common re-encoding techniques. Positive identification of video copies has been made with bit rates as low as 25 kbps.

Broadband Directional Antenna for RFID, Wireless & Mobile Devices (Licensing)
Researchers at Heriot-Watt University have developed a novel, broadband directional antenna small enough for applications in RFID (Radio Frequency Identification), Wireless devices, mobile phones and Radar communications. The principle beam of radiation can be steered in any direction with a very low backlobe. When several are combined it can provide small, mobile, wireless devices with multiple input multiple output (MIMO) communications. Benefits: • Broadband antenna technology for mobile devices • Enables MIMO communication in small devices • Reduced power usage, - extending battery life & reducing RF emissions • Allows “Angle of signal arrival” determination for location detection • Increases reliability of communication link – fewer dropped calls etc.

Developing Practice In The Workplace : Gerontological Nursing Demonstration Project (Collaborative)
A pioneering initiative to improve and sustain better care for older people. A geographically dispersed network of gerontological nurses form a learning community connected by a virtual Practice Development College. Using collaborative, solution focussed, developmental eLearning the collective knowledge of the network is harnessed and strengthened. Led by a Professorial team, they craft and demonstrate implementation of evidence based guidance, building learning resources for others. At a group and individual level eFacilitation supports members to champion change and life long learning at work. The model has been identified by the European Commission as a showcase with high transferability potential for single organisations or across organisations.

Energy Efficient Robust Liquid Crystal Display for use in Electronic Advertising (Licensing)
Researchers at the University of Strathclyde have developed a new reflective bistable liquid crystal display. This bistable technology only requires constant power to change an image, not to maintain it. This means that, for advertisements that remain static for many minutes, there is a huge saving in power consumption. Also, there is no need for the large backlight that consumes much of the power of a traditional display and makes it easier to read in direct sunlight. The display could be powered by solar energy and could operate independently of a connected electrical power source.

High survival routing for wireless networks (Licensing)
Researchers at the University of Edinburgh have developed a metric for wireless communication networks that measures a nodes capability to transmit data (ie. relay capacity) and a new routing mechanism. This technology increases route survival probability, improving throughput and efficiency of the network, increasing the energy efficiency, prolonging battery lifetime, and improving overall quality of service.

New Terahertz Radiation Source (Licensing)
Researchers at the Universities of Aberdeen and Glasgow are developing an inexpensive and powerful THz radiation source. Terahertz or THz technology is a new and exciting frontier in science and engineering with a huge number of potential applications.

Optical Field Encryption for Secure Communication (Licensing)
Researchers at Heriot-Watt University have developed a novel technique to optically encrypt communications for secure optical data transfer.

Radio Resource Metric Estimation (Licensing)
The University of Edinburgh has developed a novel Resource Metrics Mapping Function (RMMF) technology, which provides efficient multi-layer interworking, and a new Radio Resource Metric Region (RRMR), which allows for the quality of signal and acceptable link quality to be guaranteed. This combined technology enables efficient utilisation and monitoring in resource usage, using the interface between link level and system level simulations approach, which allows for a dynamic resource metric estimation.

Remote Electrical Plant Monitoring System (Licensing)
In many industry sectors, extending the longevity of plant machinery has become an increasingly important route to improving efficiency and boosting profitability. Reduced maintenance costs and improved servicing are a direct result of more effective plant monitoring. Researchers at Strathclyde have developed a remote monitoring system which measures current and voltage waveforms whilst simultaneously monitoring operating temperature at remote distances of up to 100km. Using state-of-the-art optical sensor technology, the system is unaffected by hazardous conditions and remains immune to electromagnetic interference.

Sonar Systems - Transmit Waveform System for Signal Stability in Multipath Environments (Licensing)
Heriot-Watt University research staff have developed an environmentally robust sonar system providing greater signal stability in multipath environments than current systems.

VECSEL semiconductor lasers (Licensing)
Compound semiconductors form the basis of modern optoelectronics technology, enabling specialised devices, such as semiconductor lasers, for applications in areas as diverse as optical data storage, telecommunications, and displays. VECSELs, a category of semiconductor laser, are becoming more and more popular because they offer wavelength flexibility from UV to near infra-red and Watt-level output in high-quality beams. However, existing VECSELs are cumbersome, expensive and of limited performance.

Vectorising Photographic Images (Licensing)
Researchers at the University of Glasgow have developed a novel codec which creates a revolutionary new image format from photographs whilst eliminating the problems of artefacts. A demonstrator has been developed and the technology is available for licence. This technology may be the basis for a video codec to generate an independent video image format - this would require a research phase, the University seeks partners interested in collaborating in such a project.

Construction

Adaptive Optics (within laser cavities) (Licensing)
As the power is increased in high power laser operation, there is a high heat load in the laser crystal, producing a strong thermally induced lensing effect. Efficiency falls and it progressively more difficult to ensure single transverse mode oscillation.The Institute of Photonics has successfully demonstrated thermal lensing compensation in a solid state laser using a 37-element intra-cavity adaptive optic and custom optimisation software. This technique provides automatic mode control of the laser and has the added benefit of establishing and maintaining laser alignment.

Caledonian Heritage Futures (Consultancy)
Cultural Heritage is a sector vital to Scotland’s social and economic development, which has been recognized in Scottish Enterprise’s cluster priorities, and by the Scottish Executive’s promotion of the National Cultural Strategy for Scotland. Tourism accounts for spending of nearly £4.5 billion and 193,000 jobs in the Scottish Economy. Cultural heritage provides the context and setting for social activity, involving the maintenance of community identity, and transmission of history in a tangible form. This makes it a bedrock for tourism development.

Centre for Research on Indoor Climate and Health (RICH Centre) (Consultancy)
People typically spend 90% of their lives indoors and there are well documented links between a poor indoor environment and the comfort, health and productivity of the occupants. The most effective form of health care is illness prevention. Interventions to improve the internal environment of buildings can reduce ill health, social problems and the burden on the NHS. Conditions within buildings however, depend on complex interactions between the external climate, the building fabric, installed systems, actions of occupants, and the wider socio economic environment. Effective solutions are therefore only possible by combining expertise from a wide range of disciplines.

Civil Engineering Services / Testing / Consultancy (Consultancy)
The Department of Civil Engineering at the University of Glasgow has well-equipped laboratories and facilities, some of which are unique in Scotland. The department offers testing and consultancy services to industry.

Increasing the amount of timber in construction through education, training, and research. (Collaborative)
Centre for Timber Engineering (CTE) is a focus for providing education, research and consultancy regarding use of timber in construction. Timber is a versatile and sustainable material whose use is increasing. The CTE is unique in the UK and is active in raising the knowledge and skills level in the timber industry. CTE provides high level training to building professionals in the use of timber and the implementation of standards. It improves the knowledge of timber engineering through degree and post-graduate courses. Strategic and applied research are other key features (e.g. product development/testing, knowledge transfer); commonly projects involve external partners.

Novel Gas/Vapour Sensor Technology ('Electronic Nose') (Licensing)
Researchers at the University of Glasgow have developed a gas sensor device and are currently seeking partners for collaboration.

The Glasgow Sustainability Centre (Consultancy)
Glasgow offers major opportunities in regeneration and sustainable development, with considerable investment and construction activity programmed during the coming 10 years, through for example – the M74 extension; the Glasgow Harbour project; The Clyde Re-Built Initiative; and the Glasgow Housing Association programme - Europe’s largest housing renovation and development scheme. The Glasgow Sustainability Centre was developed against this backdrop and in response to a pressing need for decision making processes and support tools, which integrate environmental, social, community, economic, scientific, and technological considerations.

Tidal energy technology (Spin-out)
Plans to make the UK a world leader in harnessing wave and tidal energy are set to receive a significant boost with this project led by Prof. Ian Bryden. Tidal currents offer a substantial predictable source of renewable energy, however at present the potential use of tidal energy is limited by installations methods for turbines, which require firm attachment to the seabed. This is very expensive and, at present, requires turbines to be placed in water depths greater than 25 metres and less than 50 metres.

Defence

Industrial Psychology Research Centre (Collaborative)
The Industrial Psychology Research Centre at the University of Aberdeen specialises in the application of psychology to the management of health, safety and emergency response in the workspace, particularly for high reliability organisations. Established in 1987 the Centre has research and consultancy experience within the oil and gas industry, nuclear and conventional power generation, civil aviation, the emergency services and hospital medicine.

Logical Image Processing (Spin-out)