Biotechnology Technology Transfer & Licensing Opportunities
Method for production of uniform GABAergic neurons from stem cells >>The University of Aberdeen has developed a novel protocol to produce homogeneous GABAergic neurons from mouse embryonic stem cells. This technology will find applications in drug screening and may have therapeutiic potential.
A new family of intracellular imaging display dyes >>Researchers at the University of Edinburgh have created a new family of fluorescein-based dyes that are in the visible range and can be used to measure intracellular pH, viscosity and temperature.
Method of treatment of Rhodococcus equi in horses >>Scientists at the University of Edinburgh have identified a target and a vaccine candidate for the treatment of Rhodococcus equi, which is recognised as the cause of a debilitating and potentially fatal bronchopneumonia affecting horses worldwide.
Highly-specific polyclonal antibody to Red Fluorescent Protein >>Researchers at the University of Edinburgh have developed a highly-specific polyclonal antibody to Red Fluorescent Protein for detecting RFP-tagged proteins.
Highly-specific polyclonal antibody to Green Fluorescent Protein >>Researchers at the University of Edinburgh have developed a highly-specific polyclonal antibody to Green Fluorescent Protein for detecting GFP-tagged proteins.
Polyclonal Antibodies to Lamins >>Researchers at the University of Edinburgh have produced rabbit polyclonal antibodies raised against the chromatin-binding domains of the human Lamin proteins A/C, B1 and B2 that give strong signals with low background and are, therefore, ideal for immunofluorescence applications.
Multi-channel Small Footprint Directly Intergrated Optical Sensors for FBG Sensor Network Interrogation >>Funded by a Scottish Enterprise Proof of Concept programme (11-DME-003) a team at Heriot-Watt University is developing lightweight high accuracy Fiber Brag Grating (FBG) network interrogators targeting applications within Civil engineering, Aerospace, biosensing and chemical detection.
Using a small footprint multi-channel design the robust sensor chip offers an alternative to existing spectrometer based solutions in FBG sensing.
High Pulse Energy Ultrafast Laser Source For Imaging, Spectroscopy & Micromachining >>Developed within Professor Derryck Reid's group, the output of the Broadband emission Ultrafast OPO laser source is suitable for applications within micromachining, waveguide fabrication and bio-imaging techniques such as multi photon, Raman or CARS spectroscopy.
High pulse energies and wavelength tuning allow a greater stand-off distance in long range spectroscopy applications.
Cystinosis - Cystagon Prodrug >>Nephropathic cystinosis is a rare autosomal recessive disease. It is characterised by raised lysosomal levels of cystine in the cells of most organs. If untreated, the disease, results in death from renal failure by the second decade of life.
Cysteamine, the treatment for cystinosis, posesses an offensive taste and smell and irritates the gastrointestinal tract leading to nausea and vomiting following administration. In addition, cysteamine and its metabolites are excreted in breath and sweat. As a result of these problems patient compliance can be poor.
Diagnostic Biomarkers for Drug-Induced Liver Injury >>Scientists at the University of Edinburgh have identified novel biomarkers present in serum and urine of patients, allowing rapid diagnosis of patients with drug-induced liver injury - a common consequence of an overdose.
Receptor-Binding Molecules as Therapeutics against Respiratory pathogens >>We have engineered a panel of recombinant proteins that have up to nanomolar affinity for
sialic acid and bind to cell surfaces. They are designed to mask the receptors of the influenza
(and parainfluenza) virus in the respiratory tract.
The recombinant therapeutic proteins are
easily produced and purified to give 15-80mg/L of bacterial cell culture. The proteins are also
susceptible to further modification.
In-vitro experiments show that the proteins are effective at blocking the entry of influenza
virus into cells in a dose-dependent manner.
The proteins are tolerated well by healthy mice;
intranasal delivery protects against influenza virus attack.
The proteins are candidate prophylactic antivirals against influenza.
Drug Eluting Stent for High-risk Patients >>Stent implantation is a highly effective treatment for restoring blood flow through an atherosclerotic artery; however restenosis occurs in a significant proportion of patients. Drug-eluting stents have been developed to limit restenosis and although they represent a major advance, they have limited effectiveness in diabetic patients. In addition, the drugs that are used at present inhibit the regrowth of the endothelium which is required to protect the artery. Thus, there is a need for an improved drug-eluting stent that will be suitable for diabetic patients, will not harm the endothelium, and will protect against blood clotting.
Novel Compound for Treatment of Psoriasis >>Psoriasis is a skin disease characterised by inflammation and scaly lesions of the skin affecting 2-3% of the population in Europe and North America. Several different therapies are currently being used to treat psoriasis, but they all have the possibility of serious side effects. Additionally, they are expensive to produce and lack efficacy in some patients.
Synthetic Low Density Lipoprotein for Animal Component Free Tissue Culture >>The recent explosion in molecular biology has led to increased demand for tissue culture media. Usually this media is supplemented with foetal calf serum which provides essential lipids to maintain cell viability and promote growth. Serum, however, is expensive and suffers from inherent biological variability, potential contamination from adventitious agents and increased regulatory scrutiny. This has led to the drive for animal component-free media but until now there has been no real animal-free lipid supplement available.
Generic FPGA core for Pairwise Sequence Alignment >>Researchers at the University of Edinburgh have developed a highly parameterised FPGA core for pairwise biological sequence alignment that provides researchers with the ability to analyse large biological data in a reasonable timeframe.
Monoclonal Antibody against mouse Mast Cell Protease-1 >>Researchers at the University of Edinburgh have produced a monoclonal antibody to mouse Mast Cell Protease-1 (mMCP-1, MCPT1). Mast cell protease-1 is used widely as a specific marker of mast cell activation after an allergic response, response to parasites, a drug-induced anaphylactoid reaction, or a consequence of a pathological condition involving mast cells.
A Novel Chemotherapy Targeting System based on Nanoparticles >>Cancer is believed to account for 12% of deaths worldwide. This incidence is increasing in Western countries, as the average age of the population increases.
The University of Strathclyde has been undertaking research into novel delivery systems for the latest drug treatments. Cisplatin, for example, is used to treat a wide variety of human cancers but many cancer cells have, or soon acquire, resistance to it.
In addition to the acquired resistance problem, there are also severe side effects associated with these drugs; due mostly to their attack on all rapidly-dividing cells within the body.
Novel Oral Drug Formulation >>Oral delivery of drugs is the most common route as it provides a safe, simple way to administer medication in a form that is easy for patients to take. Many drugs cannot be administered orally however, due to problems with degradation in the stomach, poor half life, poor solubility and bioavailability and so there is a need for new methods to formulate drugs for oral administration.
Researchers at the University of Strathclyde have developed a novel method of processing, formulating and tableting cucurbiturils as excipients in oral drug formulations to provide a method for enhanced drug formulation.
Microfluidic Chip for High Efficiency Plasma Separation for non-invasive diagnostics >>Researchers at Heriot-Watt University (Scotland) have designed a microfluidic chip capable of high efficiency separation of (whole) blood into blood plasma and red blood cell streams for further analyses.
The high flow design produces a large particle free zone shown to be 100% cell free; extracted plasma is suitable for direct PCR amplification fo the genetic material without further treatment.
Separation
Transdermal Patient Monitoring >>Control of blood glucose levels through glucose measurement and insulin injection can reduce the occurrence of complications in diabetics. Methods such as the “finger-stick” technique, while relatively cheap, can be cumbersome and painful to use. In addition to diabetes, control of blood glucose levels can play a key role in several important hospital based interventions. A team at the University of Strathclyde has perfected a non-invasive programmable device for measuring blood glucose levels. The same technology can also be adapted to detect other blood circulating molecules such as lactate.
Resorbable Polymer dental insert for slow release of bioactives or drug preparations >>Researchers at Heriot-Watt and Dundee Universities have developed a resorbable dental insert which is capable of timed release of drug preparations to prevent tooth decay.
Hand Held, Low Cost Drug Detection System for detecting Narcotics in Saliva >>Researchers at Heriot-Watt University have developed an innovative method for the presumptive detection of narcotics in saliva.
The technique offers a simple "Yes/No" result in seconds using a low powered handheld reader and economic disposable media.
Soluble Polymer Catalysts >>The project is developing commercial processes using organocatalysts for chiral chemical production. In doing so, a number of existing metal catalyst processes will be replaced. There are environmental challenges associated with recovery of the metals used (e.g., iridium, rhodium, palladium, etc.), and also cost implications necessitated by the removal of unwanted metal residues from the resulting compounds.
Improved production of glioma neural tumour stem cell lines >>Researchers in the University of Edinburgh have developed a new method of producing a neural tumour stem cell line using a reliable method of purification that retains the characteristics of the tumour from which it was derived and can be differentiated into various neural cell types.
Compostella >>Compostella is a disruptive technology, from the University of Glasgow, which permits position to be measured with extremely high precision at very low cost.
The system is physically small and highly configurable, with few limitations on mounting. Compostella will be the first single device capable of measuring in 6 axes.
Intermediate models for lung function and disease >>Researchers at the University of Edinburgh’s Roslin Institute have extensive expertise in design and implementation of preclinical trials involving the sheep lung and using the sheep as a model system for respiratory disease.
Monoclonal antibody specific for human soluble CTLA4, A novel therapeutic and diagnostic >>CTLA-4 is an important molecule in regulating the immune response. However, there is more than one genetic isoform of CTLA-4. Researchers at the University of Aberdeen have developed a monoclonal antibody clone JMW-3B3 that binds exclusively to the natural soluble isoform of CTLA4. The antibody significantly enhances targeted immune responses and has clear potential as a revolutionary therapeutic for treatment of cancer and infective disease with additional indications as a disease diagnostic or vaccine adjuvant. Additionally the antibody is available as a research reagent.
A Method for the Fabrication of Micro-Diamond Hollow Shells >>Researchers at Heriot-Watt University and the Korean Institute for Science and Technology have developed a controlled method for producing inert hollow diamond shapes for storage, preservation and transporting of materials with controlled release properties.
3D Real Time BioPhotonic Imaging & Tracking Suited to Fluoresence Microscopy Applications >>Heriot-Watt University of Edinburgh, Scotland have developed a patent pending lens system with dedicated particle tracking software to image and track cells, cell processes and small particles in real time in 3D. Compatible with existing imaging & microscopy techniques and built from commercially available optics the system offers both high quality images and positional information on biological processes within a cell.
Genespark Molecular Label >>Genespark is a fast fluorescent molecular labelling technology with unlimited multiplex scalability.
Secretory trap vector for capturing target genes >>Researchers from the University of Edinburgh have generated a modified gene trap vector, “the secretory trap”. This vector is engineered such that retention of β-gal enzyme activity in reporter gene fusions is dependent on the acquisition of a signal sequence from the endogenous gene at the site of vector insertion.
Large Animal Transgenesis >>Researchers at the University of Edinburgh’s Roslin Institute have established a method for robust and quick generation of transgenic animals from mammals other than mouse using lentiviral vectors.
A predictive biomaker and novel drug target for Lung Cancer >>Research at the University of Aberdeen focused on Non Small Cell Lung Cancer NSCLC has revealed a suite of biomarkers with significant potential as diagnostic / prognostic test. NSCLC makes up 80% of lung cancer cases. Patient outlook is bleak with 50% of those diagnosed in Scotland dying within 4 months. Treatment is by surgery and chemotherapy but resistance to chemotherapeutic agents is rife with up to 70% of patients not responding. The Aberdeen technology predicts resistance to chemotherapy drugs ensuring clinicians deliver personalised treatment for patients. Excitingly one of the biomarkers offers significant potential as a drug target.
Novel target for metastatic breast cancer >>A role for an orphan receptor in metastatic breast cancer has recently been discovered by researchers at the University of Aberdeen. The expression level of this receptor may be correlated with the invasiveness and metastatic potential of breast cancer cells. The receptor may be used as a biomarker for diagnosis of the metastatic potential of breast cancer and may also be a target for therapeutic intervention.
Bijel Capsules: Co-release Micro-gel >>Colloid scientists at the University of Edinburgh have invented a new generic route to gel capsule formulation, involving particles suspended in fluid-bicontinuous mixture of two solvents.
Bijels: Emulsion Gels Stabilized by Particles >>Researchers at the University of Edinburgh have invented a new generic route to gel formulation, involving particles suspended in fluid-bicontinuous mixture of two solvents.
Novel Mouse Model for research and study of therapeutic treatments in Psoriasis >>Researchers at the University of Dundee have developed a novel in vivo experimental system which induces the expression of human psoriatic genes without the need for human skin grafts. The mouse model demonstrates many clinical and histological effects of human Psoriasis within a period of 21 days. This reliable model provides a rapidly developed, complimentary tool for studying the development and therapeutic treatment of Psoriasis.
Technology for Improving the Solubility of Drugs >>A major problem in the development of medicines is that ~40 - 60% of new drugs discovered are poorly water-soluble. This project exploits a recent University of Strathclyde invention of a novel method of increasing the solubility and / or the dispersibility of poorly water-soluble drugs and hydrophobic particles. The technology, which will be used initially in the formulation and delivery of medicines, offers vast commercial potential as the drug delivery market is currently estimated to be worth ~£20bn worldwide with an annual growth rate of between 10% - 20%.
Chronotherapeutic Drug Delivery Platform >>The severity of many diseases such as anxiety, asthma and hypertension varies with the bodies’ internal clock. There is increasing evidence to show that these natural rhythms can also affect the bodies responsiveness to drugs and so optimal treatment of these diseases could be enhanced by delivery of the drug at the time when clinical signs develop or increase.
Method for the Identification of Allosteric Drug Binding Sites >>Natural allosteric effectors are very difficult to identify because of the complexity of cell metabolism, the practice of assaying enzymes in purified forms away from their natural context, and a general lack of success in predicting the locations of potential binding sites. However, the prediction problem has been tackled at the Uiversity of Strathclyde by development of the Simple Intrasequence Difference (SID) screening service.
Innovative Neonatal Life Support System >>The current technology employed in neonatal life support systems for children is derived from cardiopulmonary bypass (CPB) systems i.e. heart-lung machines. However, the challenges presented by non-standard CPB applications e.g. Extracorporeal Membrane Oxygenation (ECMO) for children, tissue, transplant organ perfusion and isolated limb perfusion are quite different to those of conventional CPB, rendering it a sub-optimal approach.
Scientists at the University of Strathclyde, working in conjunction with local clinicians, have developed a simple but novel life support system (controlling blood flow & oxygenation) for babies.
Live Attenuated Salmonella for Vaccine Development >>The University of Edinburgh has developed a method of producing safer, more effective, live attenuated Salmonella bacterial vaccines. This approach could be applied to the development of safer more effective vaccines for this and other infectious diseases.
Non-viral method for creating Induced Pluripotent Stem Cells >>Researchers at the University of Edinburgh and Mount Sinai Hospital in Toronto have developed a safer non-viral plasmid vector for generating induced pluripotent stem cells (iPS). The vector enables researchers to transfect in the four genes required for reprogramming of somatic cells in a single fragment. Once reprogramming is complete the genes can be removed.
Peptide Gels for 3D Cell Culture >>Commercial scaffolds for cell culture are widely used in drug discovery, cell biology and oncology, and form part of the $1.6B world wide cell based and screening analysis market. Historically, this has used 2D platforms but 3D cell matrices are increasingly used to provide a more accurate representation of such ‘wet environments’. We conservatively estimate that there are some 165,000 researchers actively engaged with in vitro cell culture worldwide.
Improved Haematopoetic Stem Cell Expansion >>Researchers at the University of Edinburgh’s Institute for Stem Cell Research at the MRC Centre for Regenerative Medicine, have discovered a method for producing large quantities of haematopoetic stem cells from embryonic or foetal tissues in the laboratory that could potentially be used to treat a wide variety of blood disorders and cancers.
Method for selecting inhibitors of Rm1A >>Bacterial cell-surface glycoconjugates are essential for survival of pathogenic bacteria and for interactions between bacteria and the host. Consequently, there is reason to believe that inhibitors directed against targets in the assembly of the cell-surface glycoconjugates may provide viable alternate therapeutic approaches. However, bacterial cell-surface glycoconjugates show remarkable structural diversity due to variations of the sugar components, linkages and substitutions. A successful strategy requires identification of enzymes and pathways unique to bacteria, yet present within a wide spectrum of bacterial species. One such target is the synthesis of the activated form of L-rhamnose.
An enzymatic process for the generation of organo-fluorine compounds >>Organo-fluorine compounds are of great importance in the fine chemical, agrochemical and pharmaceutical industries; 5-Fluorouracil and Prozac are organo-fluorine compounds. Such compounds are also prevalent in the material industry, such as ferromagnetic material and Teflon.
The technology involves the first identified fluorinase enzyme which forms C-F bonds which was isolated from the bacterium Streptomyces cattleya.
Assay for anti-viral agents >>Some picornaviruses can cause mild illnesses, such as the common cold whilst others can give rise to serious conditions of the central nervous system, heart, skeletal muscle and liver.
This assay allows the evaluation of new drug candidates to inhibit an interaction which is essential for picornaviral replication in a host cell. This efficient and economic assay may be the key step in the drug discovery and development process, by potentially identifying novel anti-viral agents.
Thymic epithelial progenitor cells >>Researchers at the University of Edinburgh have developed methodology and reagents for purifying Thymic Epithelial Progenitor cells (TEPCs) from fetal thymus tissue, improving their viability and expanding their numbers in culture. Thymic Epithelial Progenitor cells are an ideal material for use in transplantation therapy or for in vitro thymus generation. These cells could be used to restore immune function to immuno-suppressed cancer patients and improve immune tolerance in transplant patients.
Composition with potent and specific bactericidal action against Staphylococcus aureus and MRSA >>The invention comprises the combination of a cationic peptide (originally produced by the North American bullfrog Rana catesbeiana) with known potency against Gram +ve bacteria, termed Ranalexin, with a bacterially-produced endopeptidase. The combination of these two molecules results in specific inhibition of Staphylococcus aureus MRSA or MSSA (methicilin-susceptible Staphylococcus aureus).
In-Situ Heavy Metal Sensor for Contaminated Land >>Researchers at The Robert Gordon University have developed an in-situ heavy metal sensor for contaminated land. Currently samples of soil are taken at a variety of depths at suspected contaminated land sites. These are then transported back to the lab and analysed on a workbench-based spectrometer and results are conveyed back to the customer. Market research shows that existing end users are not entirely satisfied with this service. The new technology developed by The Robert Gordon University can provide an alternative that guarantees a prompt, cheap and effective result.
Diagnostic Biomarkers for Ectopic Pregnancy >>Scientists at the University of Edinburgh have identified novel biomarkers, present in the first trimester of pregnancy, for rapid identification of an ectopic or extra-uterine pregnancy. A serum-based test is estimated to generate savings of up to £1 million per year in Scotland alone.
Thin Film Centre University of the West of Scotland >>Thin Film Centre is a centre of excellence in Scotland for the development of deposition processes for thin films, the design and fabrication of thin film products, the characterisation of thin films and the dissemination of information about the applications of thin films. Contact Prof Frank Placido
Tel: +44 (0)141 848 3610, e-mail: frank.placido@paisley.ac.uk
Intelligent Cardiovascular Stent >>The use of stents has revolutionised coronary artery disease, however the main disadvantage is the occurrence of restenosis in 20-30 per cent of cases.
As in-stent restenosis is not monitored as standard practice, diagnosis only occurs when the patient presents with symptoms.
The key benefit of this technology is the ability to introduce economical occasional (clinic), or continuous (acute) monitoring of the in-stent restenosis, transmitting this data to a device outlside the body. Patients progressing to a restenosis situation, which could lead to cardiac infarction and possible death, can therefore be identified and treated.
A Novel Drug Delivery Strategy for Nasal MRSA Eradication >>MRSA (methicillin resistant S. aureus) is a potential killer infection that is endemic in our hospitals. Around 20% of the general population (patients, staff, hospital visitors) are believed to be carriers with potential to cause infection.
A research team at the University of Strathclyde has demonstrated that the use of novel formulations results in rapid adherence to the nasal mucosa by formation of viscous gels that resist removal by cilia. A sustained absorption profile is obtained, leading to reduced frequency of dosing. The novel nasal formulations (NNF) are virtually sensation free and afford prolonged residence in man.
Anti-cancer compounds:novel non-genotoxic activators of p53 >>In a collaborative project between the Universities of
Dundee and St Andrews a series of compounds activating the p53 tumour suppressor have been identified. Data is available showing one of these compounds preferably kills tumour cells expressing normal p53 and reduces tumour growth in a xenograft model.
Compounds for the development of novel asthmatic therapies and infectious diseases >>Researchers at the University of Dundee have identified a number of novel compounds that inhibit family 18 chitinasees.Specific potent inhibitors would be of considerable interest for the development of novel therapeutics with anti-fungal,or anti-inflammatory potential for asthma and other disorders.
Defined media for culturing regionalised anterior endoderm cells >>Researchers at the University of Edinburgh have developed a defined media and process for the isolation of anterior definitive endoderm (ADE) cells from embryonic stem cells. This technology offers the potential to develop a new media for the generation of ADEs and/or cell lines (eg. hepatocyte-like) for toxicology screening.
Realtime Image Registration >>Using a groundbreaking technique developed in astronomy, researchers at the University of Edinburgh are able to register complete 3D image volumes to sub-pixel accuracy in real-time. For the first time, full affine correction can be calculated and applied as an imaging sequence is acquired, vastly reducing both bulk subject motion and geometric artefacts from the images.
Methods for the Identification and Treatment of Multiple Organ Failure >>Researchers at the University of Edinburgh have identified potential compounds for the prevention and/or treatment of multiple-organ failure, as well as methods for monitoring the multiple-organ failure status of a patient.
Prion-specific antibody >>Researchers at the University of Edinburgh, together with colleagues from the Scottish National Blood Transfusion Service, Roslin Institute Neuropathogenesis Unit, and the University of Strathclyde, have developed an antibody that can distinguish abnormal PrP (PrPSc) from the normal cellular form (PrPC).
This is a major step towards the provision of a rapid and reliable screening test for the presence of the disease-associated form of the prion protein applicable to donated blood and organs for transplantation.
Novel polymeric nano-carriers for drug delivery and other biomedical applications. >>Researchers at The Robert Gordon University have engineered novel nano-sized polymeric solubilisers to encapsulate and deliver therapeutic agents such as peptides, proteins and water insoluble drugs. In the aqueous solution, these delivery systems form a protective core, which can trap and separate their cargo from the aqueous environment. Hence, they can also be designed to carry potent substances, which are easily degradable in an aqueous environment during processing/manufacturing. They are easy to prepare and due to the diverse architecture of these delivery systems, they can be tailored made to carry a broad range of molecules for biomedical application
Development of Anti-Obesity Compounds >>Obesity is a common and increasing problem. US government estimates show that 33% of people aged 20 to 74 are obese which attributes to 100,000 deaths annually, and is a major cause of heart attacks, high blood pressure, strokes, diabetes, sexual dysfunction, bowel cancer, and arthritis. Estimates of the market size for a drug treatment of obesity are $4-5 billion annually. Current therapies are inadequate however as they rarely produce a sustained weight loss and have unacceptable side-effects.
Deoxygenation >>Researchers at The Robert Gordon University have created a ceramic catalytic reactor for deoxygenating a fluid.
Plasma Treated Active Carbon Adsorbents >>Researchers at The Robert Gordon University have developed a completely new type of porous carbon for high performance filtration. The materials provide a pivotal role in the successful development of key technologies to meet current societal needs in the critical areas of energy, purification and safety/personal protection where the development of new, low cost, safety clothing and breathing apparatus for civilian and military protection against the threat of terrorist attacks is an ever increasing need.
Oxidative Stress Probe >>Fluorescent antioxidant used for the real-time measurement of the amount and rate of oxidative activity.
Improved ‘humanised’ mouse model technology >>Researchers at the University of Edinburgh have perfected a genetic engineering strategy in mouse embryonic stem cells to replace large regions of mouse chromosomal sequences (>100kb) with the corresponding human syntenic region.
Diagnostic for genetic predisposition to Autism with therapeutic potential >>This technology developed at the University of Aberdeen relates to the discovery of mutation of a single gene in individuals with classical autism. The gene is involved in protein translation and offers possibilities in the diagnostic and therapeutic markets for those with autism spectrum disorder.
Real Time Nitrate Detector >>Researchers at The Robert Gordon University have developed a new method for detecting nitrates in foodstuffs and water. This new sensor membrane uses a compound that provides a robust solution to the limitations usually found surrounding the measurements of nitrates.
By working with partners in Portugal and Spain, RGU has produced an electrode without an inner reference solution, producing a robust sensor which can detect to a limit of 10-7M – an improvement on the method currently used which struggles to detect concentrations below 10-5M.
CDK inhibitors enhance the resolution of the inflammatory response >>Scientists at the University of Edinburgh have identified a novel therapeutic strategy for the treatment of inflammatory disorders. Cyclin dependent kinase (CDK) inhibitors were shown to enhance the resolution of inflammation by inducing neutrophil apoptosis. The discovery has applications in treatment of chronic, acute and fibrogenic neutrophil mediated inflammation.
Methanesulfonanilides for the treatment of inflammatory disorders >>Scientists at the University of Edinburgh have identified a hitherto unrecognised potential of IKr-specific Class III anti-arrhythmics for the treatment of inflammatory disorders in a number of disease states/models. Class III anti- arrhythmics can modulate the recruitment of inflammatory leukocytes and phagocytosis of apoptotic infiltrated cells. The discovery has application in treatment of chronic, acute and fibrogenic mediated inflammation.
Method to determine best buffer to maintain proteins in solution >>A method to enable the rapid identification of optimal conditions for maintaining proteins in solution has been developed by the University of Dundee. This overcomes current problems in maintaining sufficient quantities of proteins in solution for further evaluation.
Organ preservation solutions to improve clinical outcome from organ transplantation >>Scientists at the University of Edinburgh have collaborated with transplantation surgeons to explore the possible benefits of novel additives to organ preservation solution. The purpose of the research was to increase the length at which organs can be preserved prior to transplantation. The preservatives work by boosting endothelium-derived agents such as nitric oxide, which improves the survival of endothelial cells in blood vessels, helping protect against vasospasm and thrombosis.
Optical Manipulator >>Scientists at the University of Edinburgh have developed a user friendly optical manipulator that interfaces to a standard port on most research grade microscopes.
Ongoing development in the COSMIC laboratory has demonstrated applications in single cell and molecule studies. Many potential applications exist in the physical and life-science fields.
Synthesis of nucleoside triphosphates >>Researchers at the University of Edinburgh have developed two novel and complimentary methods for syntheses of nucleic acids. These new systems employ polymer-supported reagents to generate nucleic acids.
Tools for rational drug discovery >>Researchers at the University of Dundee have developed methods for determining the structures of molecules. Reagents and methods for crystallization of the proteins PDK1, PKB and TAPP1, can be used in co-crystallisation studies to design modulating molecules of best fit. PRODRG is a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules. These systems can be used to design more effective drugs.
Cytochrome P450 CYP2S1 to aid the treatment of Psoriasis >>Researchers at the University of Dundee have shown that the human cytochrome P450, CYP2S1, is expressed in human skin with marked individuality in expression and induction following UVR or topical drug treatment. These data suggest a functional role for CYP2S1 in the metabolism of topical drugs, leading to improved therapeutics for psoriasis patients. A commercial partner is now sought for the development of this technology through either research collaboration or licensing.
Targeted therapy for specific autoimmune disease >>A peptide is described that selectively inactivates pathogenic T-cells responsible for autoimmune disease. Potential applications of this therapy include for example rheumatoid arthritis, psoriasis, multiple sclerosis and autoimmune haemolytic anaemia
Selectively enhancing nitric oxide activity in damaged blood vessels >>Many drugs are aimed at enhancing the therapeutic potential of nitric oxide (NO) in the cardiovascular system. These generally lack selectivity, hence there is a need to treat diseased tissues more specifically in order to restore their function. This can be achieved by boosting the natural enzymatic synthesis of NO, which is impaired in pulmonary hypertension, atherosclerosis and diabetes. Supplementation of the natural cofactor of the enzyme (tetrahydrobiopterin) has clinical efficacy, but the compound must be injected.
Antimicrobial Agent Targets in Acanthamoeba - A treatment for contact-lens induced infection >>Acanthamoeba are microscopic amoeba commonly found in the environment. Through improper storage, handling, and disinfection of contact lenses, Acanthamoeba can enter the eye and cause severe ulcerations of the cornea - a condition called Acanthamoeba keratitis. Current treatments are extremely cumbersome and often fail as Acanthamoeba can develop into cysts that are resistant to the drugs used to treat it. Even if successful, the damage to the eye can be so extensive that a cornea transplant is required. Moreover, the drug-resistant cysts remaining in the eye can re-infect the transplanted cornea.
ES-62 – A Novel Anti-Inflammatory Agent >>Chronic inflammation contributes to a broad spectrum of diseases including arthritis, psoriasis, diabetes, allergy, connective tissue diseases and heart disease. Despite the range of current therapeutics on offer, there is unmet clinical need as treatments such as corticosteroids, though often effective, are associated with serious side effects.
Oral Vaccine System >>The traditional method of administering vaccinations is by injection. This method suffers from high relative cost, low efficacy and compliance and the need for trained personnel for administration. Researchers at the University of Strathclyde have developed a system which enables the oral delivery of vaccines - “bilosomes”. This represents a major step forward in vaccine technology.
Effective Delivery of Drugs to the Lung >>There are a number of impediments to effective drug delivery. These can include erroneous absorption which reduces the concentration of the drug at the critical target site. In order to overcome this, researchers at the University of Strathclyde have pioneered a technique which delivers drugs through the use of a proprietary delivery system.
Shinkanco: A Step Forward for Alzheimer's Research and Other Neurodegenerative Disorders >>Shinkanco, a joint project between the universities of Glasgow and Strathclyde, has developed a portfolio of four early-stage programmes containing lead compounds that represent potential approaches to novel drugs to alleviate cognitive dysfunction in Alzheimer’s disease and related disorders. These include a novel protein involved in memory control, and a novel compound (and analogues) with structure unlike existing drugs.
Bio-Chip with Integrated Nano-Waveguides for High Performance Optical Analysis >>Researchers at the University of Glasgow have adapted methods from the telecommunication industry to fabricate ‘biochips’
which integrate optical and micro-fluidic components.
Technology for Improving the Accuracy of Fluorescence-Based High Density Microarray, Microplate or Biochip Readers >>Researchers at the University of Glasgow have developed technology which aims to overcome some of the known problems associated with fluorescence-based screening of biological samples.
Miniaturised Sensor of Thermal Changes in Biological Samples >>A research team at the University of Glasgow have developed a miniaturised high throughput sensor device that can be used to detect thermal changes in biological samples.
Optimal fill pattern template for use in Osteochondritis operations using mosaicplasty >>This operation involves the cutting out of cylindrical shaped areas from a diseased knee. These are then filled with smaller cylindrical plugs/grafts from a healthy part of the knee. Currently this operation involves the orthopeadic surgeon ‘guessing’ which size of grafts to use and how to arrange them in the whole for maximum coverage.
Templates developed by Glasgow Caledonian University detail the size of the cylinders required, the combination of grafts to be used to refill the hole and the arrangement required to give an optimum fill. Removing the need for guesswork on the part of the surgeon.
Centre for Biomedical and Nutritional Sciences >>BIO is virtually unique within UK Universities. No other single academic unit encompasses such a broad range of subjects / disciplines in its research portfolio. It has ‘opposite ends’ in biomedical and nutritional research that includes – cell & molecular biology; proteomics; food analysis; nutritional intake in childhood; microbiology of bacterial and viral pathogens; fungal toxins; physiology of tissue injury and modeling; pharmacology; cardiovascular and respiratory function; genetic diseases and cancer.
Centre for Vision in Health >>Glasgow Caledonian University has built a solid foundation of multi-disciplinary vision research. The Centre for Vision in Health further develops this expertise via enhanced contributions by researchers in optometry, physiology, biochemistry, psychology, physics, and microbiology. Additional medical links via the appointment of two senior academic consultant ophthalmologists have also been developed.
Centre for Risk and Governance at Glasgow Caledonian University >>Glasgow Caledonian University possesses unique national and international expertise in a number of areas applied to Governance and Risk. This is embedded across the University’s eight Schools and also several Divisions.
Novel DNA Sequencing Tools >>Researchers at the University of Glasgow have developed a new tool for rapid execution of DNA sequencing. The University is currently seeking partners interested in the commercial explotation of this research.
Improved Method of Male Fertility Testing >>Aerospace Engineers at the University of Glasgow, working with colleagues from the Section of Reproductive and Developmental Medicine at the University of Sheffield, have developed an improved method of testing male fertility. The University are currently seeking interested parties to discuss the commercial exploitation of this research.
Imaging Systems for Animated and Non-Animated Cardiac Images >>Researchers at the University of Glasgow working with Cardiologists at the Western Infirmary have developed an imaging system for animated and non-animated cardiac images. The University are seeking commercial partners to explore the commercialisation of this technology.
Clinical Assessment Software Tools for 3D Surface Anatomy Imaging >>The University of Glasgow has developed practical clinical assessment tools that utilise 3D images of the surface anatomy of a patient and which are also compatible with conventional 3D volumetric medical imaging data sources such as CT and MRI. Surface anatomy analysis algorithms, developed as part of an ongoing research programme, have been integrated with advanced statistical algorithms and packaged into a suite of intuitive, easy-to-use software tools that give the clinician significantly enhanced capabilities and can also be used to extend the capability of existing 3D volumetric data analysis techniques. Algorithms have also been devised to support statistical analysis of the true 3D shape of the imaged anatomy based on comparison of reference statistics derived from 3D images of a control group. The University is keen to begin the commercial exploitation of this technology and seeks a suitable commercial partne
Micro LED Arrays >>Micro-LED arrays provide a fundamental technology which can underpin several significant markets.
The display and lighting industry world-wide is being revolutionised by the advent of high brightness light emitting diodes (LEDs). Gallium nitride (GaN) materials technology is being used to provide devices at the blue end of the spectrum (violet/blue/green) and the same technology forms the basis of white light LEDs.
The geo-political environment of recent years has resulted in enormous sums being invested in chemical and biological sensors and biomedical diagnostics both at point of care and in the lab are rapidly growing markets.
The Institute of Photonics has developed and demonstrated a range of microLED arrays in various formats, all based on GaN growth on a sapphire substrate.
Novel Sedatives and Hypnotics from Valerian >>Extracts of valerian plants are widely and successfully used as sedatives. Preparations of plant materials are, however, variable in composition and in effectiveness. Moreover, the active components have not been identified. Some isolated components, such as valepotriates, baldrinals and valerenic acid have been studied, but their sedative activity does not explain the potency of the original extracts. The overall effect of the extract is widely assumed to result from synergistic actions of several components, although this has never been demonstrated.
UV Light Indicator >>The incidence of skin cancer has doubled in the UK in the past 20 years, now affecting 50,000 Britons every year. Protective sun creams are widely available, however if the lotion is not reapplied at the appropriate time or is rubbed or washed off, consumers are left at risk of being burned. Researchers at Strathclyde University have developed an innovative UV light indicator in the form of a simple wrist-band, which could solve this problem. A novel ink formulation printed onto the band produces a colour change warning the user once their exposure has reached recommended levels.
Nanometric Environments and Adhesion Properties >>The University is currently seeking commercial partners with which to further our research and develop the applications for use of this technology in a number of areas.
We can offer:
· Platform technology, which has the potential to be developed for use in a range of medical device applications.
· In vitro/in vivo proof of principle in a number of materials with the potential to impact greatly on the biomedical device market and other areas.
· Extensive expertise in the fields of nanotopography and cell biology.
We welcome enquiries from any company interested in evaluating this technology for in-licensing or co-development.
Meaningful Measurement for Rehabilitation, Sport, and Fitness &Leisure activities. >>An Instrumented Balance Assessment and Rehabilitation System (IBars) has been designed, constructed, and operated in a Clinical environment for more than two years. So far reliability tests, research results, and anecdotal feedback have all shown positives. The significance of quantifying balance both to Health Care providers and in the sports, and Fitness & Leisure markets must not be under-estimated. Balance and control of movement is being increasingly recognised as the forgotten factor in performance. Balance rehabilitation and quantification has applications through a wide range of client groups, from patients recovering from stroke to elite athletes.
Advanced Compression Software for Microscopy Images >>A unique image compression system has been developed in the Computing Science Department of the University of Glasgow.Developed to run under the Windows TM environment the codec
reads stacks of .tif files although it can be expanded to handle other image formats.
A whole stack of microscopy images is compressed to a single file.The codec is incorporated in a stack viewer package that allows data to be viewed along orthogonal axes, and allows maximal isometric projections of the data.Compression ratios can be selected.Monochrome and colour stacks are supported.
This technique utilises Lossy compression – therefore it is not suited to clinical diagnostics.
Portable Magnetic Resonance Imaging (MRI) >>The technology, developed at the University of Aberdeen, relates to the portable MRI system which will cost significantly less than current equipment. Most existing magnetic resonance imagers are highly sophisticated, occupy a large amount of space and are costly to purchase and maintain. There are numerous situations in which the ability to image small objects or localised areas of human or animal patients using portable equipment would be extremely valuable.
Combating Pathogenic Bacteria >>The potential for bacteriophages to control bacterial infections has been known for some time, but not fully exploited. They are not commonly used in general medical practice due, in part, to the introduction of antibiotics. However, the overuse of antibiotics has resulted in many bacterial species which have become resistant to antibiotics, a large number of which are pathogenic and expensive to treat. These include the MRSA ‘superbug’.
Breath Monitoring for Ethane Gas >>This opportunity has developed from high sensitivity ethane gas sensing applications in the oil industry. A number of potentially valuable clinical applications are now being investigated as part of a Scottish Enterprise Proof of Concept project.
The Universities of Glasgow and Dundee welcome enquiries from any organisation interested in discussing exploitation routes for this exciting development.
HTR Telomerase Promoter - Improving Suicide Gene Therapy for the Treatment of Cancer >>We have developed an Adenoviral Construct containing the telomerase hTR promoter to provide highly efficient, cancer specific transcriptional regulation capable of targeting a broad range of cancer types.
The University are currently seeking commercial partners with which to develop the use of the hTR telomerase promoter and to advance the lead constructs under development.
We welcome enquiries from any company interested in evaluating our telomerase program for in-licensing or co-development.
A Novel Kinase (SGK) Target for the Treatment of Diabetes, Cancer and Stroke >>A team of research scientists at the Wellcome Trust Biocentre at the University of Dundee have developed specific inhibitors and activators of protein kinases in the insulin signalling pathway with the aim of identifying novel drug targets for a variety of diseases including diabetes, cancer and ischaemic injury.A method of modulating SGK activity has been developed providing a screening method for new drugs or lead compounds.
Identification of New Protein Families Possessing PH Domains with Novel Phosphoinositide Binding Specifities >>Researchers at the University of Dundee have identified three new mammalian protein families which show significance in a variety of cellular pathways. These provide drug targets for the treatment of cancer, strokes and diabetes.
New Target for Antimicrobial Compounds >>A potential target for antimicrobial compounds has been developed by researchers at the University of Dundee. The highly purified target protein shows strong affinity for bacterial rRNA and is the only DEAD box protein for which a specific substrate has been identified.
Synbiotic for the Treatment of Ulcerative Colitis >>Researchers from the University of Dundee have developed a novel synbiotic formulation that promotes the growth of beneficial bacteria that will then play a key role in the treatment of ulcerative colitis. This treatment provides effective therapy by promoting the body's own defence system.
Novel compounds that regulate Angiogenesis, Cell Migration and Matrix Synthesis >>Chronic wounds are a major clinical problem caused
by failure in one of the cascade of events
underlying the normal wound repair process. MSF
is an ideal candidate for a topical therapeutic
to 'kick-start' normal healing as it induces all the
cellular events required for wound repair. The high
expression of MSF in fetal skin and adult gingival
tissue is thought to be the reason why these
tissues heal so well without any scarring.
Scotin - a novel target for cancer therapies >>University of Dundee researchers have identified and characterised a novel gene inducible by p53. Scotin is a potential target for new cancer therapies and could also form the basis of new therapeutic compounds. A commercial partner is now sought for the development of this technology through either research collaboration or licensing.
