Technology Opportunities from University Technology http://www.university-technology.com/sectors/Biotechnology Thu, 11 Mar 2010 21:56:45 +0100 FeedCreator 1.7.2 http://unitech.dogdigital.net/details/method-for-production-of-uniform-gabaergic-neurons-from-stem-cells The University of Aberdeen has developed a novel protocol to produce homogeneous GABAergic neurons from mouse embryonic stem cells. This technology will find applications in drug screening and may have therapeutiic potential. University Technology Tue, 02 Mar 2010 17:34:14 +0100 http://unitech.dogdigital.net/details/a-new-family-of-intracellular-imaging-display-dyes Researchers at the University of Edinburgh have created a new family of fluorescein-based dyes that are in the visible range and can be used to measure intracellular pH, viscosity and temperature. University Technology Thu, 25 Feb 2010 11:21:32 +0100 http://unitech.dogdigital.net/details/method-of-treatment-of-rhodococcus-equi-in-horses Scientists at the University of Edinburgh have identified a target and a vaccine candidate for the treatment of Rhodococcus equi, which is recognised as the cause of a debilitating and potentially fatal bronchopneumonia affecting horses worldwide. University Technology Wed, 24 Feb 2010 12:13:52 +0100 http://unitech.dogdigital.net/details/highly-specific-polyclonal-antibody-to-red-fluorescent-protein Researchers at the University of Edinburgh have developed a highly-specific polyclonal antibody to Red Fluorescent Protein for detecting RFP-tagged proteins. University Technology Thu, 11 Feb 2010 17:20:05 +0100 http://unitech.dogdigital.net/details/highly-specific-polyclonal-antibody-to-green-fluorescent-protein Researchers at the University of Edinburgh have developed a highly-specific polyclonal antibody to Green Fluorescent Protein for detecting GFP-tagged proteins. University Technology Thu, 11 Feb 2010 16:54:26 +0100 http://unitech.dogdigital.net/details/polyclonal-antibodies-to-lamins Researchers at the University of Edinburgh have produced rabbit polyclonal antibodies raised against the chromatin-binding domains of the human Lamin proteins A/C, B1 and B2 that give strong signals with low background and are, therefore, ideal for immunofluorescence applications. University Technology Thu, 11 Feb 2010 16:24:07 +0100 http://unitech.dogdigital.net/details/multi-channel-small-footprint-directly-intergrated-optical-sensors-for-fbg-sensor-network-interrogation Funded by a Scottish Enterprise Proof of Concept programme (11-DME-003) a team at Heriot-Watt University is developing lightweight high accuracy Fiber Brag Grating (FBG) network interrogators targeting applications within Civil engineering, Aerospace, biosensing and chemical detection. Using a small footprint multi-channel design the robust sensor chip offers an alternative to existing spectrometer based solutions in FBG sensing. University Technology Thu, 11 Feb 2010 10:19:36 +0100 http://unitech.dogdigital.net/details/high-pulse-energy-ultrafast-laser-source-for-imaging,-spectroscopy--micromachining Developed within Professor Derryck Reid's group, the output of the Broadband emission Ultrafast OPO laser source is suitable for applications within micromachining, waveguide fabrication and bio-imaging techniques such as multi photon, Raman or CARS spectroscopy. High pulse energies and wavelength tuning allow a greater stand-off distance in long range spectroscopy applications. University Technology Tue, 09 Feb 2010 14:07:37 +0100 http://unitech.dogdigital.net/details/cystinosis---cystagon-prodrug Nephropathic cystinosis is a rare autosomal recessive disease. It is characterised by raised lysosomal levels of cystine in the cells of most organs. If untreated, the disease, results in death from renal failure by the second decade of life. Cysteamine, the treatment for cystinosis, posesses an offensive taste and smell and irritates the gastrointestinal tract leading to nausea and vomiting following administration. In addition, cysteamine and its metabolites are excreted in breath and sweat. As a result of these problems patient compliance can be poor. University Technology Fri, 05 Feb 2010 16:22:14 +0100 http://unitech.dogdigital.net/details/diagnostic-biomarkers-for-drug-induced-liver-injury Scientists at the University of Edinburgh have identified novel biomarkers present in serum and urine of patients, allowing rapid diagnosis of patients with drug-induced liver injury - a common consequence of an overdose. University Technology Tue, 08 Dec 2009 11:28:57 +0100 http://unitech.dogdigital.net/details/receptor-binding-molecules-as-therapeutics-against-respiratory-pathogens We have engineered a panel of recombinant proteins that have up to nanomolar affinity for sialic acid and bind to cell surfaces. They are designed to mask the receptors of the influenza (and parainfluenza) virus in the respiratory tract. The recombinant therapeutic proteins are easily produced and purified to give 15-80mg/L of bacterial cell culture. The proteins are also susceptible to further modification. In-vitro experiments show that the proteins are effective at blocking the entry of influenza virus into cells in a dose-dependent manner. The proteins are tolerated well by healthy mice; intranasal delivery protects against influenza virus attack. The proteins are candidate prophylactic antivirals against influenza. University Technology Wed, 25 Nov 2009 05:28:34 +0100 http://unitech.dogdigital.net/details/drug-eluting-stent-for-high-risk-patients Stent implantation is a highly effective treatment for restoring blood flow through an atherosclerotic artery; however restenosis occurs in a significant proportion of patients. Drug-eluting stents have been developed to limit restenosis and although they represent a major advance, they have limited effectiveness in diabetic patients. In addition, the drugs that are used at present inhibit the regrowth of the endothelium which is required to protect the artery. Thus, there is a need for an improved drug-eluting stent that will be suitable for diabetic patients, will not harm the endothelium, and will protect against blood clotting. University Technology Mon, 02 Nov 2009 10:58:58 +0100 http://unitech.dogdigital.net/details/novel-compound-for-treatment-of-psoriasis Psoriasis is a skin disease characterised by inflammation and scaly lesions of the skin affecting 2-3% of the population in Europe and North America. Several different therapies are currently being used to treat psoriasis, but they all have the possibility of serious side effects. Additionally, they are expensive to produce and lack efficacy in some patients. University Technology Mon, 02 Nov 2009 10:03:20 +0100 http://unitech.dogdigital.net/details/synthetic-low-density-lipoprotein-for-animal-component-free-tissue-culture The recent explosion in molecular biology has led to increased demand for tissue culture media. Usually this media is supplemented with foetal calf serum which provides essential lipids to maintain cell viability and promote growth. Serum, however, is expensive and suffers from inherent biological variability, potential contamination from adventitious agents and increased regulatory scrutiny. This has led to the drive for animal component-free media but until now there has been no real animal-free lipid supplement available. University Technology Fri, 30 Oct 2009 06:47:58 +0100 http://unitech.dogdigital.net/details/generic-fpga-core-for-pairwise-sequence-alignment Researchers at the University of Edinburgh have developed a highly parameterised FPGA core for pairwise biological sequence alignment that provides researchers with the ability to analyse large biological data in a reasonable timeframe. University Technology Thu, 24 Sep 2009 05:46:16 +0100