Engineered Macrophages to Improve in vitro Red Blood Cell Maturation

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Life Sciences
Life Sciences

University: University of Edinburgh

Sector(s): Life Sciences, Life Sciences

About Opportunity:

Background

Blood transfusions are essential in treating traumatic emergency situations, as well as chronic hematological disorders. As a result, blood banks and transfusions services have a perpetual struggle with the supply of blood which also pose risks of infection and immune incompatibility.

To combat these problems production of artificial blood in the lab has garnered much interest. In particular, production of red blood cells (RBCs) is being assessed for use clinically. RBCs are generated naturally through erythropoiesis from blood stem cells, where the final stage of RBC maturation is to eject its nucleus, known as enucleation. This process is what researchers are trying to mimic in the lab. However, until now, efficient and full maturation and enucleation of stem cell-derived RBCs has not been possible.

Technology Overview

Researchers at The University of Edinburgh have successfully generated the erythroblastic island (EI) in vitro by genetically engineering stem cell-derived macrophages. The EI is an essential niche for red blood cell maturation and enucleation. When progenitor blood cells from umbilical cord or pluripotent stem cells are co-cultured with these engineered macrophages within the island, their maturation is significant improved and, crucially, enucleation efficiency is increased.

The artificial erythroblastic islands generated with this novel technique can be used to model erythropoiesis in vitro for research, as well as promoting the maturation of lab grown RBCs for potential use clinically. By improving the physiological relevance of the culture niche, the researchers have enhanced in vitro RBC generation, as well was identified key cytokines that can further augment RBC maturation and enucleation.

Stage of Development

In vitro validation

Key Benefits:

  • Physiological relevant niche
  • Improved enucleation yield from stem cell-derived RBCs
  • Modelling of human erythropoiesis
  • Identification of key cytokines for RBC maturation

Applications:

  • In vitro
  • Modelling erythropoiesis

IP Status:

PCT/GB2019/051060 with priority date 13/04/2018

Easy Access Documents:

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