Novel target for Sickle Cell Disease & other haemolytic anaemias

submit enquiry
Sickle red blood cells
Sickle red blood cells

University: University of Aberdeen

Sector(s): Healthcare & Pharmaceuticals, Life Sciences

About Opportunity:

Patients suffering from haemolytic anaemias suffer from low levels of red blood cells caused by accelerated clearance of such cells from the body. Sickle cell anaemia is a common and severe example with particular prevalence amongst people associated with populations of particular geographical locations with a history of malaria. Although stem cell treatment can be curative, a matched donor is required and risks are high. Alternative treatments that aid in management of haemolytic anaemias remain desperately needed.

University of Aberdeen researchers led by Professor Mark Vickers and Professor Robert Barker, studying efferocytosis (the disposal of old and damaged cells by the immune system) have discovered a novel mechanism by which old and damaged red blood cells are removed by macrophages. This offers a novel therapeutic approach to treat haemolytic anaemias and also shows potential utility for protection of cells in other areas such as neuro-degenerative diseases.

In vitro proof of concept demonstration of the technology has been achieved with efferocytosis of damaged or diseased red blood cells by macrophages shown to be prevented in vitro by use of decoy ligands, antibodies and siRNA approaches targeting the novel cell ligand

Key Benefits:

  • Identified target antigen is accessible for therapeutic intervention
  • Target expressed on diseased or damaged red blood cells
  • Can be used as a diagnostic to ascertain sickle cell disease severity and guide treatment
  • Potential for other areas such as neuro- degenerative diseases

Applications:

  • Novel treatments for haemolytic anaemias
  • Potentially applicable to neuro-degenerative diseases

IP Status:

A priority patent application covering the core concepts was filed on 31st October 2017 (UK application number 1717977.1)

Further information is available under CDA with the University keen to engage with parties interested in development and licensing of the technology.

Enquiry

Please enter your name.

Please enter the name of the company you work for.

Is your company an SME?

Please select the country you are in.

Please select what part of the UK you are in.

Please select from the following options.

Please enter your email address.

To help us process your enquiry faster please enter some details about the information you are interested in.

Words remaining:

Related Opportunities

  • Telomerase Promoter - Cancer Therapies

    The University of Glasgow has developed a (Ad-hTR-NTR) which has been extensively tested on Ovarian cancer cells.

    Expires: Created:
  • SNP-based assay for analysis of MRSA

    This assay is a rapid and reproducible approach for epidemiological analysis of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. The assay identifies different strains on EMRSA-15, which is a major cause of hospital acquired MRSA infections in the UK and in other parts of the wo...

    Expires: Created:
  • Catanostics - Non-Invasive Early Stage Cataract Diagnosis & Severity Quantification tool

    Catanostics (Cataract Diagnostics) offers an alternative to the slit lamp currently used for cataract diagnosis before referring a patient for cataract surgery. Our non-invasive fluorescence scan offers "better diagnosis" through non-subjective analysis of data on cataract symptoms & severity lea...

    Expires: Created:
  • Transforming Pharmaceutical Crystal Forms

    The innovation provides a gas-induced method for phase-transforming organic solids, such as pharmaceutical crystals. The inventive method subjects the polymorphs of pharmaceutical agents to various pressures of gases (such as CO2, N2O, and CH4) to induce phase transform with ease.

    Expires: Created:
  • Sperm Motility Enhancers for Assisted Reproductive Technology

    Sperm Motility Enhancers: A Novel Strategy for Assisted Reproductive Technology (ART) based on the direct relationship between human fertility and sperm motility,the University of Dundee has successfully identified FDA-approved compounds with robust and effective stimulation on patient sperm motilit...

    Expires: Created:

Alerts Signup

Sign up to our technology alerts and be the first to hear about any new technology opportunities from Scotland's universities


Register Now for University Technology.com Alerts


Search Filter

Share this page

Use the buttons below to share these technology opportunities on your favourite social networking site. You can also share them from inside the individual opportunity.