Chiral Rotational Spectroscopy

submit enquiry
Key components of a chiral rotational spectrometer
Key components of a chiral rotational spectrometer

University: University of Glasgow

Sector(s): Healthcare & Pharmaceuticals, Life Sciences

About Opportunity:

Molecular chirality is hugely important to the pharmaceutical (unichiral drug sales > $200bn to date, 95% of drugs chiral by 2020), agricultural and other industries. We offer a new technology to address the challenges currently impeding progress.

Chiral Rotational Spectroscopy (CRS) is a new technique for the analysis of chiral molecules. Sample molecules are illuminated by circularly polarised light, which shifts their rotational energy levels. Microwaves are employed to measure these shifts, via the rotational spectrum of the molecules. CRS is chirally sensitive as enantiomers experience different shifts and thus exhibit different rotational spectra. CRS can also be used to extract new information about achiral molecules.

CRS can be realised by adding circularly polarised light and a static magnetic field to a standard Balle-Flygare Fourier Transform Microwave Spectrometer.

Key Benefits:

  • Determination of orientated chiroptical information –– this offers a new and incisive handle on molecular chirality and is otherwise inaccessible (“we have a shocking small of amount of (this) data… a vast chasm in the science of molecular chirality”).
  • Measuring enantiomeric excess.
  • Probing molecular chirality of racemates –– saving time and $$$ by negating the need for dissymmetric synthesis or prior resolution
  • Inherent sensitivity to isotopic chirality –– opening the door to new products and markets (“there have been very few studies of isotope-generated chirality in biochemistry”).
  • Ability to distinguish between even subtly different molecular forms –– saving time and $$$ by negating the need for prior separation using e.g. chromatography, whilst opening the door for the analysis of molecules with multiple chiral centres (“challenging”) and enabling compliance with new legislation (USFDA).
  • These capabilities all co-exist in CRS.


  • Molecular chirality is hugely important to the pharmaceutical,agricultural and other industries.

IP Status:

GB patent application filed in December 2015.

PCT patent application filed in November 2016.

Contact is welcomed from organisations interested in developing, licensing or exploiting this IP with a view to commercialisation.


Please enter your name.

Please enter the name of the company you work for.

Is your company an SME?

Please select the country you are in.

Please select what part of the UK you are in.

Please select from the following options.

Please enter your email address.

To help us process your enquiry faster please enter some details about the information you are interested in.

Words remaining:

Related Opportunities

  • Telomerase Promoter - Cancer Therapies

    The University of Glasgow has developed a (Ad-hTR-NTR) which has been extensively tested on Ovarian cancer cells.

    Expires: Created:
  • SNP-based assay for analysis of MRSA

    This assay is a rapid and reproducible approach for epidemiological analysis of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. The assay identifies different strains on EMRSA-15, which is a major cause of hospital acquired MRSA infections in the UK and in other parts of the wo...

    Expires: Created:
  • Catanostics - Non-Invasive Early Stage Cataract Diagnosis & Severity Quantification tool

    Catanostics (Cataract Diagnostics) offers an alternative to the slit lamp currently used for cataract diagnosis before referring a patient for cataract surgery. Our non-invasive fluorescence scan offers "better diagnosis" through non-subjective analysis of data on cataract symptoms & severity lea...

    Expires: Created:
  • Transforming Pharmaceutical Crystal Forms

    The innovation provides a gas-induced method for phase-transforming organic solids, such as pharmaceutical crystals. The inventive method subjects the polymorphs of pharmaceutical agents to various pressures of gases (such as CO2, N2O, and CH4) to induce phase transform with ease.

    Expires: Created:
  • Sperm Motility Enhancers for Assisted Reproductive Technology

    Sperm Motility Enhancers: A Novel Strategy for Assisted Reproductive Technology (ART) based on the direct relationship between human fertility and sperm motility,the University of Dundee has successfully identified FDA-approved compounds with robust and effective stimulation on patient sperm motilit...

    Expires: Created:

Alerts Signup

Sign up to our technology alerts and be the first to hear about any new technology opportunities from Scotland's universities

Register Now for University Alerts

Search Filter

Share this page

Use the buttons below to share these technology opportunities on your favourite social networking site. You can also share them from inside the individual opportunity.