Thermoelectric Sensor

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Thermoelectric Sensor
Thermoelectric Sensor

University: University of Glasgow

Sector(s): Life Sciences, Chemical, Healthcare & Pharmaceuticals

About Opportunity:

Changes in temperature can be a good way to measure a chemical or biological activity, providing both real-time (kinetic) or end-point (steady-state) information. There are numerous examples of the use of this method, termed calorimetry, in use throughout analytical sciences and biotechnology.

There are a number of reactions where very small amounts of heat are produced (or consumed). This might be because the sample is very small, or because the reaction itself does not result in a large energy change.

The Thermoelectric Sensor technology is a Nano-Calorimetric Sensor which measures very small changes in temperature. The IP provides a route to making the most sensitive calorimetric measurements (with a resolution of (0.1 mK). It is also ideally suited to analysis of small samples, associated with Lab-on-a-Chip methods.

Key Benefits:

  • Faster assays allowing real-time measurements of thermal changes in biological samples
  • 96 well high throughput format compatible with existing HTS equipment – higher multiples 384, 864 and 1536 plate formats may also be used
  • Application with a wide range of biological samples including single cells, small groups of cells, tissue samples, cell-free extracts , cell organelles or isolated biochemical materials such as enzymes or components of biochemical pathways
  • Easy manufacture using known methods adapted from the semiconductor industry


  • Array Formats for High throughput drug discovery/Compound Analysis
  • Measurement of Drug Interactions with Proteins, Ligands or Receptors
  • Protein Crystallisation Studies
  • Clinical Diagnostics
  • Environmental Diagnostics
  • Gas Sensing Molecular Biology – PCR Amplification

IP Status:

This technology is available as an Easy Access deal, available to companies and individuals to licence for FREE.


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