Strategy for Enhancing the Performance of Vaccines

submit enquiry
Healthcare & Pharmaceuticals
Healthcare & Pharmaceuticals

University: University of Dundee

Sector(s): Healthcare & Pharmaceuticals, Chemical

About Opportunity:

The development of protein-based vaccines remains a major challenge in the fields of immunology and drug delivery. A significant need remains however for improved or novel vaccines, particularly for major infectious diseases such as HIV, malaria and tuberculosis, and also for cancer therapeutics.

A key requirement for vaccine efficacy is T lymphocyte activation. Protein-based vaccines are taken up by antigen presenting cells (APCs), broken down into peptides by proteases, and then displayed on MHC molecules on the surface of the APC. Researchers have now shown that too much proteolytic processing within APC can compromise antigen/vaccine presentation to T cells. Researchers at the University of Dundee have used the novel strategy of suppressing proteolytic activity to significantly enhance T cell responses. Modulation of proteolysis is obtained by a novel multifunctional protease inhibitor termed Cystatin-Pepstatin Inhibitor (CPI).

The novel multifunctional endo/lysosomal protease inhibitor inhibits all three families of the endosomal proteases in an endosome-specific manner. This strategy has the potential to provide a novel, highly effective method of improving vaccine performance and work is ongoing to test CPI as an additive to vaccine adjuvants.

Key Benefits:

  • A strategy based on proteolytic modulation
  • Modulation obtained by a novel multifunctional protease inhibitor
  • Significantly enhances T cell response


  • Vaccines for HIV, malaria and tuberculosis
  • Vaccines for cancer therapeutics

IP Status:

This technology is protected by patent (US 9050374) and three patent applications (EP 2744821, CN 103814046 and IN 1822DEN2014).


Please enter your name.

Please enter the name of the company you work for.

Is your company an SME?

Please select the country you are in.

Please select what part of the UK you are in.

Please select from the following options.

Please enter your email address.

To help us process your enquiry faster please enter some details about the information you are interested in.

Words remaining:

Related Opportunities

  • Telomerase Promoter - Cancer Therapies

    The University of Glasgow has developed a (Ad-hTR-NTR) which has been extensively tested on Ovarian cancer cells.

    Expires: Created:
  • SNP-based assay for analysis of MRSA

    This assay is a rapid and reproducible approach for epidemiological analysis of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. The assay identifies different strains on EMRSA-15, which is a major cause of hospital acquired MRSA infections in the UK and in other parts of the wo...

    Expires: Created:
  • Catanostics - Non-Invasive Early Stage Cataract Diagnosis & Severity Quantification tool

    Catanostics (Cataract Diagnostics) offers an alternative to the slit lamp currently used for cataract diagnosis before referring a patient for cataract surgery. Our non-invasive fluorescence scan offers "better diagnosis" through non-subjective analysis of data on cataract symptoms & severity lea...

    Expires: Created:
  • Transforming Pharmaceutical Crystal Forms

    The innovation provides a gas-induced method for phase-transforming organic solids, such as pharmaceutical crystals. The inventive method subjects the polymorphs of pharmaceutical agents to various pressures of gases (such as CO2, N2O, and CH4) to induce phase transform with ease.

    Expires: Created:
  • Sperm Motility Enhancers for Assisted Reproductive Technology

    Sperm Motility Enhancers: A Novel Strategy for Assisted Reproductive Technology (ART) based on the direct relationship between human fertility and sperm motility,the University of Dundee has successfully identified FDA-approved compounds with robust and effective stimulation on patient sperm motilit...

    Expires: Created:

Alerts Signup

Sign up to our technology alerts and be the first to hear about any new technology opportunities from Scotland's universities

Register Now for University Alerts

Search Filter

Share this page

Use the buttons below to share these technology opportunities on your favourite social networking site. You can also share them from inside the individual opportunity.