Transforming Pharmaceutical Crystal Forms

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Healthcare & Pharmaceuticals
Healthcare & Pharmaceuticals

University: Heriot Watt University

Sector(s): Healthcare & Pharmaceuticals, Chemical, Healthcare & Pharmaceuticals, Life Sciences

About Opportunity:

The phenomenon of polymorphism, the ability of a compound to crystallize into more than one distinct crystal species, is a major factor in the pharmaceutical industry. Gas pressurization can be used to convert polymorphs of pharmaceutical agents with ease. However, current processing methods are often lengthy and can involve the use of high temperature at great expense to the industrial sector. Our facile method of polymorph transformation eliminates the need for such measures, and offers vast potential for streamlining the processing of pharmaceutical agents, with a concomitant savings in energy costs while potentially creating new pharmaceutical entities and patent extensions. In short this innovation provides a new and improved method for controlling phase transitions among the polymorphic forms of an organic solid.

Key Benefits:

  • Establishing new drug entities with the potential to extend patent life
  • Improved efficiency in processing with significant cost savings


  • Potential applications in the field of Pharmaceutical Manufacturing

IP Status:

Demonstrated with server marketed drugs; Patent Pending.

Publication-J AM Chem Soc. 2011 Feb 9; 133(5):1399-404. Epub 2011 Jan 5

Heriot-Watt University & the University of Missouri seek industry partners with experience of pharmaceutical manufacturing or research and development within Healthcare and Pharmaceutical Sectors. Partners should have an interest in either licensing or in supporting collaborative development of the technique and its application across the Healthcare and Pharmaceutical Sector.

For Further Information Please Contact: Paul Hippenmeyer Sr. Licensing & Business Development Associate Office of Technology Management and Industry Relations


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