PVDF Glycoarray

submit enquiry
Binding Glycolipids in Cell Membranes
Binding Glycolipids in Cell Membranes

University: University of Glasgow

Sector(s): Life Sciences, Healthcare & Pharmaceuticals

About Opportunity:

Cell membranes are coated with a layer of sugar and fat molecules termed glycolipids. It is increasingly realised that glycolipids have important functions and many cell-cell interactions, adhesion, motility and signalling events are mediated by glycolipid interactions.

In Multiple Sclerosis and the inflammatory paralysis Guillain Barré syndrome, some patients have antibodies that react against their own glycolipids. Previously, such interactions and antibodies were studied by isolating single glycolipids and analysing binding by ELISA (Enzyme-linked immunosorbent assay).

The University of Glasgow has identified a novel way of looking at proteins that bind glycolipids in membranes in a new process called combinatorial glycorray. This glycoarray allows multiple complexes to be spotted onto an artificial membrane composed of polyvinyldifluoride (PVDF) which can then be used to assess binding of proteins and antibodies.

Key Benefits:

  • Automations - use of automated sampler allows multiple different combinations of glycolipids to be spotted in an efficient manner
  • Small sample size - only small volumes of test solution are required
  • Hydrophobic attachment - PVDF membranes bind glycolipids via a hydrophobic interaction with their lipid tails. As such, on PVDF, these are displayed in keeping with their in vivo orientation

Applications:

  • Screening for disease markers in autoimmune conditions such as Multiple Sclerosis and Guillain Barré syndrome
  • Identifying novel targets for bacterial cell and toxin binding
  • Screening antibodies for complex binding

IP Status:

PCT/GB2009/001665 (Pending application)

Contact is welcomed from organisations interested in developing, licensing or exploiting this technology with a view to commercialisation.

Enquiry

Please enter your name.

Please enter the name of the company you work for.

Is your company an SME?

Please select the country you are in.

Please select what part of the UK you are in.

Please select from the following options.

Please enter your email address.

To help us process your enquiry faster please enter some details about the information you are interested in.

Words remaining:

Related Opportunities

  • Lab in a Pill

    Scientists at the University of Glasgow have pioneered a new sensor technology, Lab-in-a-Pill, that could have major impact on the cost and effectiveness of bowel cancer treatment.

    Expires: Created:
  • Thermoelectric Sensor

    The Thermoelectric Sensor technology is a Nano-Calorimetric Sensor which measures very small changes in temperature. The IP provides a route to making the most sensitive calorimetric measurements (with a resolution of 0.1 mK).

    Expires: Created:
  • Parkinson's Disease Model

    The University of Glasgow is offering an exciting new model for the evaluation of new treatments for Parkinsons disease

    Expires: Created:
  • Combination Treatment for MRSA Nasal Carriage and MRSA-infected Wounds

    The new treatment is a combination of a peptide (ranalexin) with bacteria cell wall-digesting protein (lysostaphin), which specifically targets and kills Staphylococcus aureus, including MRSA.

    Expires: Created:
  • Synergistic antifungal combination

    Candida species are a major cause of catheter-related nosocomial bloodstream infections. We have identified that the combination of an echinocandin antifungal with certain antimicrobial peptides results in potent, synergistic inhibition of yeast pathogens in vitro, so offering a potential combinatio...

    Expires: Created:

Alerts Signup

Sign up to our technology alerts and be the first to hear about any new technology opportunities from Scotland's universities


Register Now for University Technology.com Alerts


Search Filter

Share this page

Use the buttons below to share these technology opportunities on your favourite social networking site. You can also share them from inside the individual opportunity.