Preparation of highly pure N-Formyl Benzotriazoles

submit enquiry

University: University of Glasgow

Sector(s): Chemical

About Opportunity:

Formylation is an integral part of organic, medicinal and biological chemistry both in industrial and academic set-ups.

Current formylating procedures suffer a number of disadvantages:

  • formic halides and formic anhydrides, tend to suffer from stability problems and are easily degraded upon storage. 
  • cyanomethyl formate is a very useful reagent, although it is difficult to prepare.
  • isopropenyl formate is a very fast and efficient reagent, but its synthesis requires a multi-step sequence. 
  • coupling agents have also been used in conjunction with formic acid to achieve N- and O-formylation, however, the removal of the side products derived from the coupling agents is often labour intensive.

N-formyl benzotriazole is a stable and convenient reagent to achieve quick and efficient N- and O- formylation of alcohols, amines and even amides in mild and selective manner.  The main challenge is the synthesis of N-formyl benzotriazole and its purification from the amount of urea by products.

Our patent protected synthesis of N-formyl benzotriazoles offers a product with much greater yield and higher purity compared to any previously known syntheses. The N-formyl benzotriazole is obtained by reacting a benzotriazole compound with a formyl anhydride.

Key Benefits:

  • Our new method of the synthesis of the N-formyl benzotriazole family of compound overcomes all of the following issues:
  • greater yield and purity compared to previously known syntheses.
  • •uses low molecular weight reagents that are readily produced from commercially available and cheap starting materials.
  • faster compared to known procedures.
  • avoids the need for carbodiimide coupling reagents, and thereby avoid the problems associated with the removal of carbodiimide-derived urea by-products.
  • suitable for large-scale production of N-formyl benzotriazoles on a multi gram scale without loss of yield or purity.


  • N-formyl benzotriazole is a stable and convenient reagent to achieve quick and efficient N- and O- formylation of alcohols, amines and even amides in mild and selective manner.

IP Status:

A patent for this synthetic procedure was filed on 21 December 2010.

This technology is available as an Easy Access IP deal, available to companies and individuals to license for FREE.


Please enter your name.

Please enter the name of the company you work for.

Is your company an SME?

Please select the country you are in.

Please select what part of the UK you are in.

Please select from the following options.

Please enter your email address.

To help us process your enquiry faster please enter some details about the information you are interested in.

Words remaining:

Related Opportunities

  • Preparation of Enantiomerically Pure Chiral Amines

    Researchers at the University of St Andrews have developed a synthetic process for the preparation of a class of enantiomerically pure chiral amines. This efficient and economical method gives rise to entities of a varied structural class, which can be used as building blocks in the synthesis of bio...

    Expires: Created:
  • Metathesis of Cardanol

    Processing cashew nuts produces 300,000 tonnes of waste by-products p.a.; 85% of this waste is made up of Cardanol. Metathesis of cardanol with ethane (ethenolysis) converts cardanol it into 1-octene a major plasticiser for polyethylene, and into 3-nonylphenol, to replace 4-nonylphenol in detergent ...

    Expires: Created:
  • Improved, more efficient ethenolysis reactions with Grubbs type catalysts

    The metathesis of alkenes with ethene, ethenolysis, is one of the most important and difficult of all metathesis reactions. We have developed processes that allow improved and efficient ethenolysis reactions to occur using cheap, readily available off-patent catalysts.

    Expires: Created:

Alerts Signup

Sign up to our technology alerts and be the first to hear about any new technology opportunities from Scotland's universities

Register Now for University Alerts

Search Filter

Share this page

Use the buttons below to share these technology opportunities on your favourite social networking site. You can also share them from inside the individual opportunity.