Preparation of Enantiomerically Pure Chiral Amines

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Chemical
Chemical

University: University of St Andrews

Sector(s): Chemical, Energy & Renewables

About Opportunity:

Researchers at the University of St Andrews have developed a synthetic process for the preparation of a class of enantiomerically pure chiral amines. This efficient and economical method gives rise to entities of a varied structural class, which can be used as building blocks in the synthesis of bioactives or catalysts for asymmetric synthesis. This novel technology has diverse applications and may prove to be a substantial benefit to service companies which synthesize novel compound libraries focussing upon compound purity and pharmacological properties. The amines also contribute new entities for the development of organocatalysts. Additional information is available under a Confidentiality Agreement.

Key Benefits:

  • Readily available and inexpensive materials
  • High yield of desired compounds
  • Established protocol
  • Produces diverse compounds from amino acids
  • Produces enantiomerically pure amines
  • Allows for the incorporation of a fluorine atom.

Applications:

  • Production of enantiomerically pure compounds- compounds are available in different enantiomerically pure forms starting from either L or D amino acids.
  • Production of Fluorine labelled compounds - the synthetic process can be adopted to enable fluorine incorporation. This can offer significant and advantageous changes to physical properties, and influence pharmacokinetics.

IP Status:

The University of St Andrews has applied for a UK and international patent protection. As yet, there are no commercial parties involved. The University would welcome enquiries from commercial parties interested in entering in entering into a licensing arrangement.

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