Results For: Healthcare & Pharmaceuticals

Showing 1 - 10 of 56 opportunities

  • A potential therapeutic approach to Spinal Muscular Atrophy (SMA)

    The neurodegenerative inherited disease Spinal Muscular Atrophy (SMA) is the leading genetic cause of infant mortality, affecting 1:6,000 live births. SMA causes a loss of spinal motor neurons and is characterised by progressive muscular atrophy.

    Expires: Created:
  • Topology specific security holograms

    The most prominent high security holographic anti-counterfeiting techniques include dot-matrix holograms and electron beam defined holograms. Both techniques require laser illumination, and the image can be viewed with a screen, CCD, or directly by the human eye.

    Expires: Created:
  • Improved experience for children and adults in visual field testing

    This optometry device uses a technique that is more natural for the patient than current gold standard visual field tests for diagnosing ophthalmologic conditions, resulting in more comfortable experience for patients and thus accessible to a wider patient group, including young children.

    Expires: Created:
  • One step prodrug trigger for targeted release of drugs

    A tetrazine small-molecule trigger for activating prodrugs has been developed. Active molecules, such as a therapeutic drug or imaging fluorophore, can be caged within a polymer nanoparticle for controlled release at a targeted site.

    Expires: Created:
  • Novel compound series to treat African trypanosomiasis

    Novel compound series of phosphofructokinase allosteric inhibitors which show excellent efficacy in vitro against the parasite and in mouse models of the disease in vivo. The well characterised inhibitors of this novel trypanosomiasis target have the potential to fill the unmet need for safe, cheap,...

    Expires: Created:
  • Potential treatment for allergic disease including severe steroid resistant asthma

    A novel approach shows promising results as a potential therapeutic for allergic conditions, including severe steroid resistant asthma. A peptide has been identified, HpARI, that inactivates and inhibits release of IL-33 a critical step in the development of allergic disease.

    Expires: Created:
  • Novel and selective inhibitors of SRC family kinases

    Novel compounds displaying high potency and selectivity toward SRC family kinases have been developed. The lead compound eCF506 displays subnanomolar potency against SRC, high selectivity over ABL kinase (1000-fold), optimal pharmacokinetic profile and in vivo target engagement.

    Expires: Created:
  • App for accurate detection and monitoring of delirium

    Delirium is an acute and severe deterioration in mental function, which affects attention and cognition and poses a significant health problem for older patients in hospital. DelApp is a novel app based cognitive test, which can objectively detect delirium in patients.

    Expires: Created:
  • CxxC domain for isolation and determination of methylation status of CpG islands

    A protein domain (CxxC) has been discovered, which is capable of specifically binding non-methylated CpG islands (CGIs). A method for generation of CpG island library and a simple two-step, column-based process have been developed using this protein domain to separate CGIs from bulk DNA.

    Expires: Created:
  • SNP-based assay for analysis of MRSA

    This assay is a rapid and reproducible approach for epidemiological analysis of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. The assay identifies different strains on EMRSA-15, which is a major cause of hospital acquired MRSA infections in the UK and in other parts of the wo...

    Expires: Created:

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