Results For: Healthcare & Pharmaceuticals

Showing 11 - 20 of 53 opportunities

  • Novel compound series to treat African trypanosomiasis

    Novel compound series of phosphofructokinase allosteric inhibitors which show excellent efficacy in vitro against the parasite and in mouse models of the disease in vivo. The well characterised inhibitors of this novel trypanosomiasis target have the potential to fill the unmet need for safe, cheap,...

    Expires: Created:
  • Potential treatment for allergic disease including severe steroid resistant asthma

    A novel approach shows promising results as a potential therapeutic for allergic conditions, including severe steroid resistant asthma. A peptide has been identified, HpARI, that inactivates and inhibits release of IL-33 a critical step in the development of allergic disease.

    Expires: Created:
  • Novel and selective inhibitors of SRC family kinases

    Novel compounds displaying high potency and selectivity toward SRC family kinases have been developed. The lead compound eCF506 displays subnanomolar potency against SRC, high selectivity over ABL kinase (1000-fold), optimal pharmacokinetic profile and in vivo target engagement.

    Expires: Created:
  • App for accurate detection and monitoring of delirium

    Delirium is an acute and severe deterioration in mental function, which affects attention and cognition and poses a significant health problem for older patients in hospital. DelApp is a novel app based cognitive test, which can objectively detect delirium in patients.

    Expires: Created:
  • SNP-based assay for analysis of MRSA

    This assay is a rapid and reproducible approach for epidemiological analysis of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. The assay identifies different strains on EMRSA-15, which is a major cause of hospital acquired MRSA infections in the UK and in other parts of the wo...

    Expires: Created:
  • Paget's disease genetic markers

    These genetic markers have an identified association with the individual prediction of susceptibility and severity of Paget's disease of the bone.

    Expires: Created:
  • FluPep - Peptide-based therapy of influenza virus infection

    This anti-influenza therapy offers potential as anti-viral treatment as well as prevention against all major flu strains, including influenza A infection.

    Expires: Created:
  • High accuracy, low blood volume microarray-based test for bacterial sepsis

    A host-directed diagnostic methodology, which uses only 30 μL of whole blood, and enables rapid and accurate detection of sepsis in neonates and other subjects. The test removes false negative results associated with current gold standard microbiological methods.

    Expires: Created:
  • Polymers for binding or repelling bacteria

    This range of novel synthetic polymers control bacterial attachment, resulting in specific sequestration or repulsion of bacteria such as Salmonella and E. coli.

    Expires: Created:
  • Biopolymer coatings for enhanced endothelialisation of intra-vascular devices

    These fully synthetic biocompatible polymers support effective human endothelial cell growth and endothelialisation, whilst minimising platelet attachment. The polymer materials can be applied as a thin coating to intra‐vascular devices and have the potential to minimise problems associated with vas...

    Expires: Created:

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