Results For: "treatment"

Showing 1 - 10 of 24 opportunities

  • A potential therapeutic approach to Spinal Muscular Atrophy (SMA)

    The neurodegenerative inherited disease Spinal Muscular Atrophy (SMA) is the leading genetic cause of infant mortality, affecting 1:6,000 live births. SMA causes a loss of spinal motor neurons and is characterised by progressive muscular atrophy.

    Expires: Created:
  • One step prodrug trigger for targeted release of drugs

    A tetrazine small-molecule trigger for activating prodrugs has been developed. Active molecules, such as a therapeutic drug or imaging fluorophore, can be caged within a polymer nanoparticle for controlled release at a targeted site.

    Expires: Created:
  • Novel compound series to treat African trypanosomiasis

    Novel compound series of phosphofructokinase allosteric inhibitors which show excellent efficacy in vitro against the parasite and in mouse models of the disease in vivo. The well characterised inhibitors of this novel trypanosomiasis target have the potential to fill the unmet need for safe, cheap,...

    Expires: Created:
  • Potential treatment for allergic disease including severe steroid resistant asthma

    A novel approach shows promising results as a potential therapeutic for allergic conditions, including severe steroid resistant asthma. A peptide has been identified, HpARI, that inactivates and inhibits release of IL-33 a critical step in the development of allergic disease.

    Expires: Created:
  • FluPep - Peptide-based therapy of influenza virus infection

    This anti-influenza therapy offers potential as anti-viral treatment as well as prevention against all major flu strains, including influenza A infection.

    Expires: Created:
  • High accuracy, low blood volume microarray-based test for bacterial sepsis

    A host-directed diagnostic methodology, which uses only 30 μL of whole blood, and enables rapid and accurate detection of sepsis in neonates and other subjects. The test removes false negative results associated with current gold standard microbiological methods.

    Expires: Created:
  • New prodrug strategy for targeted chemotherapies

    This new approach converts chemotherapy agents into prodrugs, significantly reducing systemic toxicity, and enabling local activation only at tumour sites where a specific catalyst, palladium, has been implanted.

    Expires: Created:
  • Rapid detection of antimicrobial resistance (AMR) & antibiotic sensitivity testing (AST)

    Antibiotics are often prescribed inappropriately leading to (1) patients remaining infected and failing to recover from bacterial infection, and (2) the spread of bacterial antibiotic resistance. Our laboratory prototype devices can provide accurate detection and quantification of bacterial suscepti...

    Expires: Created:
  • Rapid, sensitive counting of viable bacteria: the Molecular Bacterial Load Assay (MBLA)

    The Molecular Bacterial Load Assay (MBLA) provides a rapid and sensitive way to detect viable bacteria. MBLA opens up new applications in the diagnosis and treatment monitoring of a range of chronic bacterial infections, representing an opportunity to create a completely new platform of bacterial di...

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  • TEMo: Gene Signatures for Breast Cancer Diagnosis

    The presence of cancer causes changes to the immune system. A 13-gene signature characteristic of the presence of breast cancer has been identified from blood samples, and a diagnostic to identify this signature as a means of detecting breast cancer more effectively than existing methods has been de...

    Expires: Created:

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