Results For: "therapy"

Showing 1 - 10 of 11 opportunities

  • Novel and selective inhibitors of SRC family kinases

    Novel compounds displaying high potency and selectivity toward SRC family kinases have been developed. The lead compound eCF506 displays subnanomolar potency against SRC, high selectivity over ABL kinase (1000-fold), optimal pharmacokinetic profile and in vivo target engagement.

    Expires: Created:
  • Paget's disease genetic markers

    These genetic markers have an identified association with the individual prediction of susceptibility and severity of Paget's disease of the bone.

    Expires: Created:
  • FluPep - Peptide-based therapy of influenza virus infection

    This anti-influenza therapy offers potential as anti-viral treatment as well as prevention against all major flu strains, including influenza A infection.

    Expires: Created:
  • Method for generating large quantities of mast cells for use in allergy drug research

    An improved method for robust and rapid production of large quantities of homogeneous mast cells suitable for research, drug discovery and cell therapy to treat allergy, anaphylaxis and autoimmune disorders.

    Expires: Created:
  • New prodrug strategy for targeted chemotherapies

    This new approach converts chemotherapy agents into prodrugs, significantly reducing systemic toxicity, and enabling local activation only at tumour sites where a specific catalyst, palladium, has been implanted.

    Expires: Created:
  • Novel adjunct therapy to eliminate opioid tolerance and mitigate side effects

    Researchers at the University of Dundee have identified an adjunct to opioid therapy that suppresses the development of tolerance and may mitigate other severe side effects associated with opioid use.

    Expires: Created:
  • Biomarker assay to enable safe corticosteroid withdrawal

    Using hypothesis-free metabolomics screening, a list of seven biomarkers has been identified that, when combined, are highly sensitive in predicting corticosteroid dose and, thus, the risk of adrenal insufficiency on corticosteroid withdrawal. Quantitative assays for these metabolites will create a ...

    Expires: Created:
  • Therapeutic target for treating vascular pathologies

    A long non-coding RNA target that regulates the proliferation of vascular smooth muscle cells, is present in the plasma of cardiovascular disease patients, and found at increased levels in unstable regions of atherosclerotic plaques. Therapeutic targeting of this molecule could inhibit vascular remo...

    Expires: Created:
  • Combination Treatment for MRSA Nasal Carriage and MRSA-infected Wounds

    The new treatment is a combination of a peptide (ranalexin) with bacteria cell wall-digesting protein (lysostaphin), which specifically targets and kills Staphylococcus aureus, including MRSA.

    Expires: Created:
  • Synergistic antifungal combination

    Candida species are a major cause of catheter-related nosocomial bloodstream infections. We have identified that the combination of an echinocandin antifungal with certain antimicrobial peptides results in potent, synergistic inhibition of yeast pathogens in vitro, so offering a potential combinatio...

    Expires: Created:

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