Results For: "therapeutic"

Showing 1 - 10 of 11 opportunities

  • Novel target for Sickle Cell Disease & other haemolytic anaemias

    A novel therapeutic target for sickle cell disease and other haemolytic anaemias

    Expires: Created:
  • A potential therapeutic approach to Spinal Muscular Atrophy (SMA)

    The neurodegenerative inherited disease Spinal Muscular Atrophy (SMA) is the leading genetic cause of infant mortality, affecting 1:6,000 live births. SMA causes a loss of spinal motor neurons and is characterised by progressive muscular atrophy.

    Expires: Created:
  • One step prodrug trigger for targeted release of drugs

    A tetrazine small-molecule trigger for activating prodrugs has been developed. Active molecules, such as a therapeutic drug or imaging fluorophore, can be caged within a polymer nanoparticle for controlled release at a targeted site.

    Expires: Created:
  • Potential treatment for allergic disease including severe steroid resistant asthma

    A novel approach shows promising results as a potential therapeutic for allergic conditions, including severe steroid resistant asthma. A peptide has been identified, HpARI, that inactivates and inhibits release of IL-33 a critical step in the development of allergic disease.

    Expires: Created:
  • Paget's disease genetic markers

    These genetic markers have an identified association with the individual prediction of susceptibility and severity of Paget's disease of the bone.

    Expires: Created:
  • Biopolymer coatings for enhanced endothelialisation of intra-vascular devices

    These fully synthetic biocompatible polymers support effective human endothelial cell growth and endothelialisation, whilst minimising platelet attachment. The polymer materials can be applied as a thin coating to intra‐vascular devices and have the potential to minimise problems associated with vas...

    Expires: Created:
  • New prodrug strategy for targeted chemotherapies

    This new approach converts chemotherapy agents into prodrugs, significantly reducing systemic toxicity, and enabling local activation only at tumour sites where a specific catalyst, palladium, has been implanted.

    Expires: Created:
  • Strategy for Enhancing the Performance of Vaccines

    Researchers at the University of Dundee have designed and synthesised a novel, multifunctional protease inhibitor that has the potential to significantly enhance the performance of vaccines through proteolytic modulation.

    Expires: Created:
  • Therapeutic target for treating vascular pathologies

    A long non-coding RNA target that regulates the proliferation of vascular smooth muscle cells, is present in the plasma of cardiovascular disease patients, and found at increased levels in unstable regions of atherosclerotic plaques. Therapeutic targeting of this molecule could inhibit vascular remo...

    Expires: Created:
  • Telomerase Promoter - Cancer Therapies

    The University of Glasgow has developed a (Ad-hTR-NTR) which has been extensively tested on Ovarian cancer cells.

    Expires: Created:

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