Results For: "drug"

Showing 1 - 10 of 17 opportunities

  • One step prodrug trigger for targeted release of drugs

    A tetrazine small-molecule trigger for activating prodrugs has been developed. Active molecules, such as a therapeutic drug or imaging fluorophore, can be caged within a polymer nanoparticle for controlled release at a targeted site.

    Expires: Created:
  • Novel compound series to treat African trypanosomiasis

    Novel compound series of phosphofructokinase allosteric inhibitors which show excellent efficacy in vitro against the parasite and in mouse models of the disease in vivo. The well characterised inhibitors of this novel trypanosomiasis target have the potential to fill the unmet need for safe, cheap,...

    Expires: Created:
  • Potential treatment for allergic disease including severe steroid resistant asthma

    A novel approach shows promising results as a potential therapeutic for allergic conditions, including severe steroid resistant asthma. A peptide has been identified, HpARI, that inactivates and inhibits release of IL-33 a critical step in the development of allergic disease.

    Expires: Created:
  • Novel and selective inhibitors of SRC family kinases

    Novel compounds displaying high potency and selectivity toward SRC family kinases have been developed. The lead compound eCF506 displays subnanomolar potency against SRC, high selectivity over ABL kinase (1000-fold), optimal pharmacokinetic profile and in vivo target engagement.

    Expires: Created:
  • App for accurate detection and monitoring of delirium

    Delirium is an acute and severe deterioration in mental function, which affects attention and cognition and poses a significant health problem for older patients in hospital. DelApp is a novel app based cognitive test, which can objectively detect delirium in patients.

    Expires: Created:
  • FluPep - Peptide-based therapy of influenza virus infection

    This anti-influenza therapy offers potential as anti-viral treatment as well as prevention against all major flu strains, including influenza A infection.

    Expires: Created:
  • Method for generating large quantities of mast cells for use in allergy drug research

    An improved method for robust and rapid production of large quantities of homogeneous mast cells suitable for research, drug discovery and cell therapy to treat allergy, anaphylaxis and autoimmune disorders.

    Expires: Created:
  • New prodrug strategy for targeted chemotherapies

    This new approach converts chemotherapy agents into prodrugs, significantly reducing systemic toxicity, and enabling local activation only at tumour sites where a specific catalyst, palladium, has been implanted.

    Expires: Created:
  • Sperm Motility Enhancers for Assisted Reproductive Technology

    Sperm Motility Enhancers: A Novel Strategy for Assisted Reproductive Technology (ART) based on the direct relationship between human fertility and sperm motility,the University of Dundee has successfully identified FDA-approved compounds with robust and effective stimulation on patient sperm motilit...

    Expires: Created:
  • Strategy for Enhancing the Performance of Vaccines

    Researchers at the University of Dundee have designed and synthesised a novel, multifunctional protease inhibitor that has the potential to significantly enhance the performance of vaccines through proteolytic modulation.

    Expires: Created:

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