Novel Cathelicidin-Based Anti-Infective
Figure above shows a trout cathelicidin derived peptide killing the fish bacterial pathogen Vibrio anguillarum in culture. The minimum inhibitory concentration (MIC) was 2 uM for this bacterial strain.
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The novel anti-infective, from rainbow trout, acts by interacting with the microbial cell membrane and is the first example of the cloning, expression and isolation of a non-mammalian cathelicidin. The anti-infective may be administered either as a therapeutic or as a prophylactic to prevent infection and could also be employed to raise antibodies to screen expression libraries for related molecules which exhibit anti-infective properties.
The novel anti-infective, in either a polypeptide, peptide or nucleic acid form, may have application as a therapeutic to treat fungal or bacterial infections, including those caused by drug resistant strains, such as E. coli, Salmonella enteritides, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Serratia marcescens, Burkholderia cepacia, Staphylococcus aureus (MRSA i.e. methicillin resistant), Staphylococcus epidermidis, Enterococcus faecalis (VREF i.e. vancomycin resistant) and Streptococcus agalactiae, and also against fungi such as Candida albicans, Candida glabrata and Cryptococcus neoformans.
Key Benefits
- Novel anti infective
- Likely to be effective against a wide range of infections
- Potential to be used as a pharmaceutical for clinical and veterinary uses and also in aquaculture
Applications
- The anti-infective may be administered as a prophylactic to prevent infection.
- Has application in both aquaculture and as a pharmaceutical for clinical and veterinary use.
- Potential to be applied as a therapeutic to treat fungal or bacterial infections, including those caused by drug resistant strains.
IP Status
This opportunity is available for licensing from the University of Aberdeen.
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