Monoclonal Antibody against mouse Mast Cell Protease-1

Immunofluorescent image of cultured bone marrow derived mast cells, with the monoclonal labelling mast cell granules (in red) and nuclear labelling in green

LICENSING OPPORTUNITY

Researchers at the University of Edinburgh have produced a monoclonal antibody to mouse Mast Cell Protease-1 (mMCP-1, MCPT1).

Mast cell protease-1 is used widely as a specific marker of mast cell activation after an allergic response, response to parasites, a drug-induced anaphylactoid reaction, or a consequence of a pathological condition involving mast cells.

This is the only currently available monoclonal antibody to mMCP1. Current alternatives are either less specific polyclonal antibodies or a similar rat mast cell protease-2 antibody.

It is type IgG1 and has been tested in Western Blot, Immunohistochemistry, immunofluorescence and ELISA.

Microgamme quantities of the -chymase mouse mast cell protease-1 (mMCPT-1) are released systematically and can be detected in peripheral blood during intestinal nematode infection and food allergy models.

Key Benefits

Ability to clearly and easily detect an allergic response in mouse models using established techniques (ELISA, Western blot, IHC) as:
- Mast cell protease -1 is an extremely sensitive marker and enters the circulation at 100-fold higher concentrations in mice than those of typtase in human allergic patients
- Mast cell protease-1 clears slowly from the circulation with a half-life of >10 hrs

Applications

Detection of the Mast Cell Protease 1 in mouse, one of the genes most highly expressed in an allergic or parasitic response through:
- Immunoblotting
- Immunohistochemistry and immunofluorescence
- ELISA

IP Status

The University of Edinburgh is seeking interest from commercial organisations to in-license this hybridoma to manufacture and sell the monoclonal antibody for research purposes.

This technology is available to license under a standard non-exclusive license agreement via Click-thru Licensing at the University of Edinburgh.
View Click-thru Licensing Opportunity and License Agreement

If you would like further information about this opportunity please fill out the form below. Your enquiry will be passed on to the relevant University who will respond to you directly.

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