Method for the Identification of Allosteric Drug Binding Sites
The Simple Intrasequence Difference (SID) screening service identifies allosteric binding sites and protein-protein interaction sites in a client’s chosen target. When provided with structural data on the target, SID will generate co-ordinates for these sites and conduct a kinetic evaluation to determine the likelihood of a drug interaction at the site. These results can be used for the identification of novel hit compounds.
Key Benefits
- Identification of novel allosteric binding sites offering modulatory, rather than all-or-nothing control of the target
- Virtual screening of allosteric binding sites will reveal compounds likely to offer greater selectivity than compounds binding at conventional sites
- Allosteric binding sites offer greater IP potential, even for well-validated targets
Applications
- SID is applicable to any protein target implicated in disease for which crystal structure information is available
IP Status
SID researchers will identify potential allosteric binding site co-ordinates and subject the target to a molecular dynamics simulation in order to confirm druggability. Co-ordinates will be provided to the client on a fee-for-service basis.
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