Assay for anti-viral agents
Our invention, which was developed by Dr. Martin Ryan, is an assay to evaluate the ability of new drug candidates to inhibit an interaction which is essential for picornaviral replication in a host cell. This efficient and economic assay may be the key step in the drug discovery and development process, by potentially identifying novel anti-viral agents.
The assay is applicable to the following picornaviruses: aphthoviruses, rhinoviruses, cardioviruses, enteroviruses, parechoviruses and hepatoviruses. In addition, it can also be applied to the following calciviruses: Feline Calcivirus (FECV); and Southampton virus (SV).Key Benefits
- Biochemical screening assay based upon the interaction between picornavirus protein 2C and dual specificity kinase anchoring protein AKAP10 (D-AKAP2);
- Readily available and inexpensive materials;
- Established protocol;
- Identifies hit and lead candidates for further development.
Applications
- The assay can be used to screen both peptides and non-peptidal compounds.
- The assay is a versatile technology and is applicable to the following picornaviruses: aphthoviruses, rhinoviruses, cardioviruses, enteroviruses, parechoviruses and hepatoviruses. In addition, it can also be applied to the following calciviruses: Feline Calcivirus (FECV); and Southampton virus (SV). Such diverse applications may prove to be of substantial benefit to pharmaceutical and biotechnology companies which screen peptides and non-peptidal compounds to select novel antiviral agents for further development
IP Status
The University of St. Andrews has been granted European (No. 1342084B) and US (No. 7,148,022) patent protection. As yet, there are no commercial parties involved. The University would welcome enquiries from commercial parties interested in entering into a licensing arrangement.
University of St Andrews, Knowledge Transfer Centre,
The Gateway, North Haugh, St Andrews, Fife. KY16 9SS
Tel: +44 (0)1334 462163
Fax: +44 (0)1334 462386
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